Translocation of proteins occurs either during translation (co-translational translocation) or after translation (post-translational translocation) and depends on the N'-terminal signal-recognition particle (SRP). The SRP interacts with a SRP receptor on the ER and promotes transport of proteins into the ER lumen where they are prepared for secretion.

Cat. No. Product Name / Activity
1231 Brefeldin A
Disrupts protein translocation to Golgi
4417 DBeQ
Selective and reversible p97 ATPase inhibitor
5172 FLI 06
Inhibitor of Notch signaling
3584 Golgicide A
Arrests secretion of soluble and membrane-associated proteins
1987 Leptomycin B
Inhibits nuclear export of proteins; antitumor
5153 ML 240
ATP-competitive inhibitor of p97 ATPase
6180 NMS 873
Potent and selective p97 ATPase (VCP) allosteric inhibitor