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Discontinued ProductGatifloxacin (Cat. No. 3849) has been withdrawn from sale for commercial reasons.
Biological Activity for Gatifloxacin
Fluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro.
Technical Data for Gatifloxacin
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Gatifloxacin
References are publications that support the biological activity of the product.
Takei et al (1998) Inhibitory activities of gatiflo. (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob.Agents Chemother. 42 2678 PMID: 9756776
Desbordes et al (2008) High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602 PMID: 18522853
Fukuda et al (1998) Antibacterial activity of gatiflo. (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob.Agents Chemother. 42 1917 PMID: 9687384
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Citations for Gatifloxacin
Citations are publications that use Tocris products.
Currently there are no citations for Gatifloxacin.
Reviews for Gatifloxacin
Average Rating: 5 (Based on 1 Review.)
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Gatifloxacin was used to understand its resistance pattern against S. aureus. E. coli strains were grown in Luria-Bertani medium, and S. aureus strains were grown in brain heart infusion medium for resistance study.
Literature in this Area
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