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Cat.No. 3849 - Gatifloxacin | C19H22FN3O4 | CAS No. 112811-59-3
Description: Antibiotic; inhibits bacterial type II topoisomerase
Alternative Names: AM 1155
Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity

Fluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro.

Technical Data

M. Wt 375.39
Formula C19H22FN3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 112811-59-3
PubChem ID 5379
Smiles O=C2C(C(O)=O)=CN(C3CC3)C1=C(OC)C(N4CC(C)NCC4)=C(F)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.75 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 375.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.64 mL 133.19 mL 266.39 mL
0.5 mM 5.33 mL 26.64 mL 53.28 mL
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL

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References are publications that support the biological activity of the product.

Takei et al (1998) Inhibitory activities of gatiflo. (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob.Agents Chemother. 42 2678 PMID: 9756776

Desbordes et al (2008) High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602 PMID: 18522853

Fukuda et al (1998) Antibacterial activity of gatiflo. (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob.Agents Chemother. 42 1917 PMID: 9687384

If you know of a relevant reference for Gatifloxacin, please let us know.

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Citations for Gatifloxacin

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Gatifloxacin was used to understand its resistance pattern against S. aureus.
By Anonymous on 02/09/2019
Species: Human

Gatifloxacin was used to understand its resistance pattern against S. aureus. E. coli strains were grown in Luria-Bertani medium, and S. aureus strains were grown in brain heart infusion medium for resistance study.

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