Pricing Availability   Qty
Description: Gibberellin-analog (GA3) chemical dimerizer; cell permeable
Chemical Name: (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester
Purity: ≥90% (HPLC)

Biological Activity for GA3-AM

GA3-AM is a Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.

Technical Data for GA3-AM

M. Wt 418.44
Formula C22H26O8
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1373154-68-7
PubChem ID 56835187
Smiles [H][C@@]12[C@@](C[C@@]3(O)CC2)(CC3=C)[C@@H](C(OCOC(C)=O)=O)[C@]4([H])[C@@]5(C)[C@@H](O)C=C[C@]41OC5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GA3-AM

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.84 100
ethanol 41.84 100

Preparing Stock Solutions for GA3-AM

The following data is based on the product molecular weight 418.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.9 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for GA3-AM

References are publications that support the biological activity of the product.

Lin et al (2013) Rapidly reversible manipulation of molecular activities using dual chemical dimerizers Angew.Chem.Int.Ed.Engl. 52 6450 PMID: 23649661

Miyamoto et al (2012) Rapid and orthogonal logic gating with a gibberellin-induced dimerization system Nat.Chem.Biol. 8 465 PMID: 22446836

If you know of a relevant reference for GA3-AM, please let us know.

Keywords: GA3-AM, GA3-AM supplier, Chemical, dimerizer, cell, permeable, chemically, inducible, dimerization, system, Biochemicals, and, Molecular, Biology, Protein, Dimerizers, 5407, Tocris Bioscience

Citations for GA3-AM

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