Discontinued Product

GA3-AM (Cat. No. 5407) has been withdrawn from sale for commercial reasons.
Description: Gibberellin-analog (GA3) chemical dimerizer; cell permeable
Chemical Name: (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester
Purity: ≥90% (HPLC)
Citations (2)

Biological Activity for GA3-AM

GA3-AM is a Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.

Technical Data for GA3-AM

M. Wt 418.44
Formula C22H26O8
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1373154-68-7
PubChem ID 56835187
Smiles [H][C@@]12[C@@](C[C@@]3(O)CC2)(CC3=C)[C@@H](C(OCOC(C)=O)=O)[C@]4([H])[C@@]5(C)[C@@H](O)C=C[C@]41OC5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GA3-AM

References are publications that support the biological activity of the product.

Lin et al (2013) Rapidly reversible manipulation of molecular activities using dual chemical dimerizers Angew.Chem.Int.Ed.Engl. 52 6450 PMID: 23649661

Miyamoto et al (2012) Rapid and orthogonal logic gating with a gibberellin-induced dimerization system Nat.Chem.Biol. 8 465 PMID: 22446836

Keywords: GA3-AM, GA3-AM supplier, Chemical, dimerizer, cell, permeable, chemically, inducible, dimerization, system, Biochemicals, and, Molecular, Biology, Protein, Dimerizers, 5407, Tocris Bioscience

2 Citations for GA3-AM

Citations are publications that use Tocris products. Selected citations for GA3-AM include:

Xi et al (2022) Passage number affects differentiation of sensory neurons from human induced pluripotent stem cells. Sci Rep 12 15869 PMID: 36151116

Yong Chul et al (2019) 5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses through Src kinase in the dendrites of rat jaw-closing motoneurons. J Physiol 597 2565-2589 PMID: 30919966

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