You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 244.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.09 mL||20.47 mL||40.94 mL|
|5 mM||0.82 mL||4.09 mL||8.19 mL|
|10 mM||0.41 mL||2.05 mL||4.09 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
References are publications that support the biological activity of the product.
Eriksen et al (2003) NSAIDs and enantiomers of flurbip. target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440 PMID: 12897211
Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54 PMID: 17650315
If you know of a relevant reference for Flurizan, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Flurizan, Flurizan supplier, NSAIDs, gamma, secretase, inhibitors, inhibits, AB42, beta, amyloid, flurbiprofen, tarenflurbil, R-flurbiprofen, Aβ42, and, Abeta42, gamma-secretase, amyloidbeta, amyloidb, amyloidβ, (R)-Flurbiprofen, Gamma-Secretase, Amyloid, Beta, Peptides, 4495, Tocris Bioscience
Citations for Flurizan
Citations are publications that use Tocris products.
Currently there are no citations for Flurizan. Do you know of a great paper that uses Flurizan from Tocris? Please let us know.
Reviews for Flurizan
There are currently no reviews for this product. Be the first to review Flurizan and earn rewards!
Have you used Flurizan?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.