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Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Eriksen et al (2003) NSAIDs and enantiomers of flurbip. target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440 PMID: 12897211
Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54 PMID: 17650315
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Keywords: Flurizan, Flurizan supplier, NSAIDs, gamma, secretase, inhibitors, inhibits, AB42, beta, amyloid, flurbiprofen, tarenflurbil, R-flurbiprofen, Aβ42, and, Abeta42, gamma-secretase, amyloidbeta, amyloidb, amyloidβ, (R)-Flurbiprofen, Gamma-Secretase, Amyloid, Beta, Peptides, 4495, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.