Discontinued Product

Flurizan (Cat. No. 4495) has been withdrawn from sale for commercial reasons.
Cat.No. 4495 - Flurizan | C15H13FO2 | CAS No. 51543-40-9
Description: γ-secretase inhibitor; lowers Aβ42 levels in vitro
Alternative Names: (R)-Flurbiprofen
Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.

Technical Data

M. Wt 244.26
Formula C15H13FO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51543-40-9
PubChem ID 92337
Smiles FC1=C(C2=CC=CC=C2)C=CC([C@@H](C)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Eriksen et al (2003) NSAIDs and enantiomers of flurbip. target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440 PMID: 12897211

Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54 PMID: 17650315

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View all γ-Secretase Inhibitors

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