Flurizan

Pricing Availability Delivery Time Qty
Cat.No. 4495 - Flurizan | C15H13FO2 | CAS No. 51543-40-9
Description: γ-secretase inhibitor; lowers Aβ42 levels in vitro
Alternative Names: (R)-Flurbiprofen
Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.

Compound Libraries

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Technical Data

M. Wt 244.26
Formula C15H13FO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51543-40-9
PubChem ID 92337
InChI Key SYTBZMRGLBWNTM-SNVBAGLBSA-N
Smiles FC1=C(C2=CC=CC=C2)C=CC([C@@H](C)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.43 100
ethanol 24.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 244.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Eriksen et al (2003) NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440 PMID: 12897211

Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54 PMID: 17650315


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View all γ-Secretase Inhibitors

Keywords: NSAIDs gamma secretase inhibitors inhibits AB42 beta amyloid flurbiprofen tarenflurbil R-flurbiprofen Aβ42 and Abeta42 gamma-secretase amyloidbeta amyloidb amyloidβ (R)-Flurbiprofen Gamma-Secretase

Citations for Flurizan

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Literature in this Area

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Pathways for Flurizan

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