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Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 477.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.19 mL||20.95 mL||41.89 mL|
|2.5 mM||0.84 mL||4.19 mL||8.38 mL|
|5 mM||0.42 mL||2.09 mL||4.19 mL|
|25 mM||0.08 mL||0.42 mL||0.84 mL|
References are publications that support the biological activity of the product.
Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223
Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunar. Life.Sci. 48 1881 PMID: 1850815
Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246
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Keywords: Flunarizine dihydrochloride, Flunarizine dihydrochloride supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Voltage-gated, Cav3.x, 0522, Tocris Bioscience
Citations for Flunarizine dihydrochloride
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To alter neuronal activity in vitro.
Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.