Flunarizine dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0522 - Flunarizine dihydrochloride | C26H26F2N2.2HCl | CAS No. 30484-77-6
Description: Dual Na+/Ca2+ channel (T-type) blocker
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Reviews (1)

Biological Activity

Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Compound Libraries

Flunarizine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 477.42
Formula C26H26F2N2.2HCl
Storage Desiccate at RT
CAS Number 30484-77-6
PubChem ID 5282407
Smiles Cl[H].Cl[H].FC1=CC=C(C=C1)C(N1CCN(C\C=C\C2=CC=CC=C2)CC1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.87 50
ethanol 2.39 5

Preparing Stock Solutions

The following data is based on the product molecular weight 477.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223

Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunarizine. Life.Sci. 48 1881 PMID: 1850815

Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246

If you know of a relevant reference for Flunarizine dihydrochloride, please let us know.

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Flunarizine dihydrochloride, supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Voltage-gated, Sodium, Channels, Voltage-gated, Calcium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

Citations for Flunarizine dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Flunarizine dihydrochloride. Do you know of a great paper that uses Flunarizine dihydrochloride from Tocris? If so please let us know.

Reviews for Flunarizine dihydrochloride

Average Rating: 4 (Based on 1 Review)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Flunarizine dihydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Filter by:

Pharmacological manipulation of neuronal activity
By Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: primary neurons

To alter neuronal activity in vitro.

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling