Flunarizine dihydrochloride

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Cat.No. 0522 - Flunarizine dihydrochloride | C26H26F2N2.2HCl | CAS No. 30484-77-6
Description: Dual Na+/Ca2+ channel (T-type) blocker
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Datasheet
Citations
Literature

Biological Activity

Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Compound Libraries

Flunarizine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 477.42
Formula C26H26F2N2.2HCl
Storage Desiccate at RT
CAS Number 30484-77-6
PubChem ID 5282407
InChI Key RXKMOPXNWTYEHI-RDRKJGRWSA-N
Smiles Cl[H].Cl[H].FC1=CC=C(C=C1)C(N1CCN(C\C=C\C2=CC=CC=C2)CC1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.87 50
ethanol 2.39 5

Preparing Stock Solutions

The following data is based on the product molecular weight 477.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223

Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunarizine. Life.Sci. 48 1881 PMID: 1850815

Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246


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View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Dual Na+/Ca2+ channel T-type blockers Sodium NaV Channels voltage-gated voltage-dependent Na+ Calcium CaV Ca2+ Voltage-gated Sodium Channels

Citations for Flunarizine dihydrochloride

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Pathways for Flunarizine dihydrochloride

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