Flunarizine dihydrochloride

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Cat.No. 0522 - Flunarizine dihydrochloride | C26H26F2N2.2HCl | CAS No. 30484-77-6
Description: Dual Na+/Ca2+ channel (T-type) blocker
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Reviews (1)
Literature (5)

Biological Activity

Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Technical Data

M. Wt 477.42
Formula C26H26F2N2.2HCl
Storage Desiccate at RT
CAS Number 30484-77-6
PubChem ID 5282407
Smiles Cl[H].Cl[H].FC1=CC=C(C=C1)C(N1CCN(C\C=C\C2=CC=CC=C2)CC1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 2.39 5
DMSO 23.87 50

Preparing Stock Solutions

The following data is based on the product molecular weight 477.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.19 mL 20.95 mL 41.89 mL
2.5 mM 0.84 mL 4.19 mL 8.38 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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References are publications that support the biological activity of the product.

Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223

Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunar. Life.Sci. 48 1881 PMID: 1850815

Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246

If you know of a relevant reference for Flunarizine dihydrochloride, please let us know.

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Keywords: Flunarizine dihydrochloride, Flunarizine dihydrochloride supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Voltage-gated, Cav3.x, 0522, Tocris Bioscience

Citations for Flunarizine dihydrochloride

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Filter by:

Pharmacological manipulation of neuronal activity.
By Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: primary neurons

To alter neuronal activity in vitro.

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