Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 477.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.09 mL||10.47 mL||20.95 mL|
|5 mM||0.42 mL||2.09 mL||4.19 mL|
|10 mM||0.21 mL||1.05 mL||2.09 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223
Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunarizine. Life.Sci. 48 1881 PMID: 1850815
Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246
If you know of a relevant reference for Flunarizine dihydrochloride, please let us know.
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Keywords: Dual Na+/Ca2+ channel T-type blockers Sodium NaV Channels voltage-gated voltage-dependent Na+ Calcium CaV Ca2+ Voltage-gated Sodium Channels
Citations for Flunarizine dihydrochloride
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