Flunarizine dihydrochloride

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Cat.No. 0522 - Flunarizine dihydrochloride | C26H26F2N2.2HCl | CAS No. 30484-77-6
Description: Dual Na+/Ca2+ channel (T-type) blocker
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Datasheet
Citations
Reviews (1)
Literature (5)

Biological Activity

Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Compound Libraries

Flunarizine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 477.42
Formula C26H26F2N2.2HCl
Storage Desiccate at RT
CAS Number 30484-77-6
PubChem ID 5282407
InChI Key RXKMOPXNWTYEHI-RDRKJGRWSA-N
Smiles Cl[H].Cl[H].FC1=CC=C(C=C1)C(N1CCN(C\C=C\C2=CC=CC=C2)CC1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 2.39 5
DMSO 23.87 50

Preparing Stock Solutions

The following data is based on the product molecular weight 477.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.19 mL 20.95 mL 41.89 mL
2.5 mM 0.84 mL 4.19 mL 8.38 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223

Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunar. Life.Sci. 48 1881 PMID: 1850815

Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246


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Keywords: Flunarizine dihydrochloride, Flunarizine dihydrochloride supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Voltage-gated, Cav3.x, 0522, Tocris Bioscience

Citations for Flunarizine dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Flunarizine dihydrochloride. Do you know of a great paper that uses Flunarizine dihydrochloride from Tocris? Please let us know.

Reviews for Flunarizine dihydrochloride

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Pharmacological manipulation of neuronal activity.
By Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: primary neurons

To alter neuronal activity in vitro.


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