FH 535

Pricing Availability   Qty
Description: Inhibitor of Wnt/β-catenin signaling
Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Pathways (1)

Biological Activity for FH 535

FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Compound Libraries for FH 535

FH 535 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FH 535

M. Wt 361.2
Formula C13H10Cl2N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 108409-83-2
PubChem ID 3463933
InChI Key AXNUEXXEQGQWPA-UHFFFAOYSA-N
Smiles ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FH 535

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.09 75

Preparing Stock Solutions for FH 535

The following data is based on the product molecular weight 361.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.69 mL 18.46 mL 36.91 mL
3.75 mM 0.74 mL 3.69 mL 7.38 mL
7.5 mM 0.37 mL 1.85 mL 3.69 mL
37.5 mM 0.07 mL 0.37 mL 0.74 mL

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References for FH 535

References are publications that support the biological activity of the product.

Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521 PMID: 18347139


If you know of a relevant reference for FH 535, please let us know.

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View all β-catenin Inhibitors

Keywords: FH 535, FH 535 supplier, FH535, wnt, beta-catenin, inhibitors, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist, Beta-catenin, Receptors, 4344, Tocris Bioscience

4 Citations for FH 535

Citations are publications that use Tocris products. Selected citations for FH 535 include:

Lan et al (2017) Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Res 27 1002-1019 PMID: 28621328

Craig B et al (2017) Metabolic origins of spatial organization in the tumor microenvironment. Proc Natl Acad Sci U S A 114 2934-2939 PMID: 28246332

Qunyuan et al (2018) Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells. Cell Biochem Funct 36 331-341 PMID: 30028031

Stefan et al (2022) The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function. Eur Respir J 59 PMID: 34561292


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Pathways for FH 535

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.