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Description: Inhibitor of Wnt/β-catenin signaling
Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Biological Activity for FH 535
FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
Compound Libraries for FH 535
FH 535 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for FH 535
| M. Wt | 361.2 |
| Formula | C13H10Cl2N2O4S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 108409-83-2 |
| PubChem ID | 3463933 |
| InChI Key | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
| Smiles | ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FH 535
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.09 | 75 |
Preparing Stock Solutions for FH 535
The following data is based on the product molecular weight 361.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 3.69 mL | 18.46 mL | 36.91 mL |
| 3.75 mM | 0.74 mL | 3.69 mL | 7.38 mL |
| 7.5 mM | 0.37 mL | 1.85 mL | 3.69 mL |
| 37.5 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for FH 535
References for FH 535
References are publications that support the biological activity of the product.
Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521 PMID: 18347139
If you know of a relevant reference for FH 535, please let us know.
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Keywords: FH 535, FH 535 supplier, FH535, wnt, beta-catenin, inhibitors, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist, Beta-catenin, Receptors, 4344, Tocris Bioscience
4 Citations for FH 535
Citations are publications that use Tocris products. Selected citations for FH 535 include:
Stefan et al (2022) The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function. Eur Respir J 59 PMID: 34561292
Lan et al (2017) Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Res 27 1002-1019 PMID: 28621328
Craig B et al (2017) Metabolic origins of spatial organization in the tumor microenvironment. Proc Natl Acad Sci U S A 114 2934-2939 PMID: 28246332
Qunyuan et al (2018) Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells. Cell Biochem Funct 36 331-341 PMID: 30028031
Do you know of a great paper that uses FH 535 from Tocris? Please let us know.
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Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pathways for FH 535
