FH 535

Pricing Availability Delivery Time Qty
Cat.No. 4344 - FH 535 | C13H10Cl2N2O4S | CAS No. 108409-83-2
Description: Inhibitor of Wnt/β-catenin signaling
Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Compound Libraries

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Technical Data

M. Wt 361.2
Formula C13H10Cl2N2O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 108409-83-2
PubChem ID 3463933
InChI Key AXNUEXXEQGQWPA-UHFFFAOYSA-N
Smiles ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.09 75

Preparing Stock Solutions

The following data is based on the product molecular weight 361.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.69 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521 PMID: 18347139


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View Related Products by Target

Keywords: FH 535, FH 535 supplier, FH535, wnt, beta-catenin, inhibitors, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist, Beta-catenin, Receptors, 4344, Tocris Bioscience

Citations for FH 535

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Reviews for FH 535

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for FH 535

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.