Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
FH 535 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 361.2 |
Formula | C13H10Cl2N2O4S |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 108409-83-2 |
PubChem ID | 3463933 |
InChI Key | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
Smiles | ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 27.09 | 75 |
The following data is based on the product molecular weight 361.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.75 mM | 3.69 mL | 18.46 mL | 36.91 mL |
3.75 mM | 0.74 mL | 3.69 mL | 7.38 mL |
7.5 mM | 0.37 mL | 1.85 mL | 3.69 mL |
37.5 mM | 0.07 mL | 0.37 mL | 0.74 mL |
References are publications that support the biological activity of the product.
Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521 PMID: 18347139
If you know of a relevant reference for FH 535, please let us know.
Keywords: FH 535, FH 535 supplier, FH535, wnt, beta-catenin, inhibitors, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist, Beta-catenin, Receptors, 4344, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for FH 535. Do you know of a great paper that uses FH 535 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review FH 535 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.