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Description: Enhances iPSC-derived hepatocyte differentiation and maturation
Alternative Names: NSC 12407, BRD-K4477
Chemical Name: N,N'-(Methylenedi-4,1-phenylene)bis-acetamide
Purity: ≥99% (HPLC)
Biological Activity for FH 1
FH 1 enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes; also promotes the maturation of iPSC-derived hepatocytes.
Compound Libraries for FH 1
FH 1 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for FH 1
| M. Wt | 282.34 |
| Formula | C17H18N2O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 2719-05-3 |
| PubChem ID | 94990 |
| InChI Key | OEXMNSOPAKOPEF-UHFFFAOYSA-N |
| Smiles | CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FH 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.23 | 100 |
Preparing Stock Solutions for FH 1
The following data is based on the product molecular weight 282.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets for FH 1
References for FH 1
References are publications that support the biological activity of the product.
Shan et al (2013) Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat.Chem.Biol. 9 514 PMID: 23728495
If you know of a relevant reference for FH 1, please let us know.
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Citations for FH 1
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