FH 1

Pricing Availability Delivery Time Qty
Cat.No. 5254 - FH 1 | C17H18N2O2 | CAS No. 2719-05-3
Description: Enhances iPSC-derived hepatocyte differentiation and maturation
Alternative Names: NSC 12407, BRD-K4477
Chemical Name: N,N'-(Methylenedi-4,1-phenylene)bis-acetamide
Purity: ≥99% (HPLC)

Biological Activity

Enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes; also promotes the maturation of iPSC-derived hepatocytes.

Compound Libraries

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Technical Data

M. Wt 282.34
Formula C17H18N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 2719-05-3
PubChem ID 94990
Smiles CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 282.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Shan et al (2013) Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat.Chem.Biol. 9 514 PMID: 23728495

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Keywords: FH1 Enhances iPSC-derived hepatocyte differentiation maturation induced pluripotent stem cell NSC12407 NSC 12407 BRD-K4477 ESCs and iPSC

Citations for FH 1

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for FH 1


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