FG 7142

Pricing Availability Delivery Time Qty
Cat.No. 0554 - FG 7142 | C13H11N3O | CAS No. 78538-74-6
Description: Benzodiazepine inverse agonist
Chemical Name: N-Methyl-β-carboline-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.

Compound Libraries

FG 7142 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 225.25
Formula C13H11N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 78538-74-6
PubChem ID 4375
InChI Key QMCOPDWHWYSJSA-UHFFFAOYSA-N
Smiles CNC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 16.89 75
DMSO 22.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 225.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.2 mL 44.4 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 340 352 PMID: 2478895

Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355 PMID: 2765936

Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313 PMID: 3032657

Wettstei (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219 PMID: 2498110


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Keywords: FG 7142, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, FG7142, GABAA, Receptors, Tocris Bioscience

4 Citations for FG 7142

Citations are publications that use Tocris products. Selected citations for FG 7142 include:

Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci 107 733 PMID: 22554617

Major et al (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci 85 753 PMID: 19837095

Lukkes et al (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav 107 719 PMID: 22583860

Lukkes et al (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res 1443 1 PMID: 22297173


Do you know of a great paper that uses FG 7142 from Tocris? If so please let us know.

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