Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 225.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.44 mL||22.2 mL||44.4 mL|
|5 mM||0.89 mL||4.44 mL||8.88 mL|
|10 mM||0.44 mL||2.22 mL||4.44 mL|
|50 mM||0.09 mL||0.44 mL||0.89 mL|
References are publications that support the products' biological activity.
Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 340 352 PMID: 2478895
Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355 PMID: 2765936
Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313 PMID: 3032657
Wettstei (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219 PMID: 2498110
If you know of a relevant reference for FG 7142, please let us know.
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Keywords: FG 7142, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, FG7142, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
4 Citations for FG 7142
Citations are publications that use Tocris products. Selected citations for FG 7142 include:
Lukkes et al (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav 107 719 PMID: 22583860
Lukkes et al (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res 1443 1 PMID: 22297173
Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci 107 733 PMID: 22554617
Major et al (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci 85 753 PMID: 19837095
Do you know of a great paper that uses FG 7142 from Tocris? If so please let us know.
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