FG 7142

Pricing Availability Delivery Time Qty
Cat.No. 0554 - FG 7142 | C13H11N3O | CAS No. 78538-74-6
Description: Benzodiazepine inverse agonist
Chemical Name: N-Methyl-β-carboline-3-carboxamide
Purity: ≥99% (HPLC)
Citations (4)

Biological Activity

Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.

Compound Libraries

FG 7142 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 225.25
Formula C13H11N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 78538-74-6
PubChem ID 4375
Smiles CNC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 16.89 75
DMSO 22.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 225.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.2 mL 44.4 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 340 352 PMID: 2478895

Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355 PMID: 2765936

Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313 PMID: 3032657

Wettstei (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219 PMID: 2498110

If you know of a relevant reference for FG 7142, please let us know.

View Related Products by Target

View Related Products by Product Action

View all GABAA Receptor Benzodiazepines

Keywords: FG 7142, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, FG7142, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

4 Citations for FG 7142

Citations are publications that use Tocris products. Selected citations for FG 7142 include:

Lukkes et al (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav 107 719 PMID: 22583860

Lukkes et al (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res 1443 1 PMID: 22297173

Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci 107 733 PMID: 22554617

Major et al (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci 85 753 PMID: 19837095

Do you know of a great paper that uses FG 7142 from Tocris? If so please let us know.

Reviews for FG 7142

There are currently no reviews for this product. Be the first to review FG 7142 and earn rewards!

Have you used FG 7142?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.


Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.