Evans Blue tetrasodium salt
Potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 960.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.04 mL||5.2 mL||10.41 mL|
|5 mM||0.21 mL||1.04 mL||2.08 mL|
|10 mM||0.1 mL||0.52 mL||1.04 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References are publications that support the products' biological activity.
Price and Raymond (1996) Evans blue antagonizes both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates desensitization. Mol. Pharmacol. 50 1665 PMID: 8967991
Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. J.Neurochem. 65 96 PMID: 7790899
Wittenburg et al (1996) P2-purinoceptor antagonists:II blockade of P2-purinoceptor subtypes and ecto-nucleotidase by compounds related to Evans blue and trypan blue. Naunyn Schmiedebergs Arch.Pharmacol. 354 491 PMID: 8897453
Schurmann et al (1997) Differential modulation of AMPA receptor mediated currents by Evans Blue in postnatal rat hippocampal neurones. Br.J.Pharmacol. 121 237 PMID: 9154333
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