Potent mTOR inhibitor (IC50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of eCF 309 is reviewed on the Chemical Probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 383.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.04 mL||65.2 mL||130.41 mL|
|1 mM||2.61 mL||13.04 mL||26.08 mL|
|2 mM||1.3 mL||6.52 mL||13.04 mL|
|10 mM||0.26 mL||1.3 mL||2.61 mL|
References are publications that support the biological activity of the product.
Fraser et al (2016) eCF309: a potent, selective and cell-permeable mTOR inhibitor. Med.Chem.Commun. 4 471
If you know of a relevant reference for eCF 309, please let us know.
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