eCF 309

Discontinued Product

eCF 309 (Cat. No. 5955) has been withdrawn from sale for commercial reasons.
Description: Potent mTOR inhibitor
Chemical Name: 3-(2-Amino-5-benzoxazolyl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for eCF 309

eCF 309 is a potent mTOR inhibitor (IC50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable. is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of eCF 309 is reviewed on the Chemical Probes website.

Technical Data for eCF 309

M. Wt 383.41
Formula C18H21N7O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2001571-40-8
PubChem ID 122163152
Smiles CCOC(OCC)CN1N=C(C2=CC(N=C(N)O3)=C3C=C2)C4=C1N=CN=C4N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for eCF 309

References are publications that support the biological activity of the product.

Fraser et al (2016) eCF309: a potent, selective and cell-permeable mTOR inhibitor. Med.Chem.Commun. 4 471

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Citations for eCF 309

Citations are publications that use Tocris products.

Currently there are no citations for eCF 309.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for eCF 309

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.