Dynamin inhibitory peptide, myristoylated

Discontinued Product

Dynamin inhibitory peptide, myristoylated (Cat. No. 1775) has been withdrawn from sale for commercial reasons.
Description: Cell-permeable dynamin inhibitor
Purity: ≥95% (HPLC)
Citations (4)

Biological Activity

Dynamin inhibitory peptide, myristoylated is a cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.

Control Peptide also available.

Technical Data

M. Wt 1330.64
Formula C61H107N19O14

(Modifications: Gln-1 = Myr-Gln, Pro-10 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 251634-22-7
PubChem ID 90471171
Smiles [H]N([C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920

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Keywords: Dynamin inhibitory peptide, myristoylated, Dynamin inhibitory peptide, myristoylated supplier, Cell-permeable, dynamin, inhibitors, inhibits, Dynamin, Epac, GTPases, Mitosis, 1775, Tocris Bioscience

4 Citations for Dynamin inhibitory peptide, myristoylated

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated include:

Kolpak et al (2009) Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. Circ Res 29 10488 PMID: 19710302

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS One 10 e0131430 PMID: 26102354

Choi et al (2005) Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. PLoS One 97 363 PMID: 16051887

Preta et al (2015) Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J 29 1516 PMID: 25550455

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