Dynamin inhibitory peptide, myristoylated

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Cat.No. 1775 - Dynamin inhibitory peptide, myristoylated | Myr-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-NH2 | CAS No. 251634-22-7
Description: Cell-permeable dynamin inhibitor
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.

Control Peptide also available.

Technical Data

M. Wt 1330.64
Formula C61H107N19O14
Sequence QVPSRPNRAP

(Modifications: Gln-1 = Myr-Gln, Pro-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 251634-22-7
PubChem ID 90471171
InChI Key IFTSFTVOMZTNME-ZUSDHBTASA-N
Smiles [H]N([C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1330.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.75 mL 3.76 mL 7.52 mL
5 mM 0.15 mL 0.75 mL 1.5 mL
10 mM 0.08 mL 0.38 mL 0.75 mL
50 mM 0.02 mL 0.08 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920


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Keywords: Dynamin inhibitory peptide, myristoylated, supplier, Cell-permeable, dynamin, inhibitors, inhibits, Dynamin, Epac, GTPases, Mitosis, GTPase, Mitosis, GTPase, Tocris Bioscience

4 Citations for Dynamin inhibitory peptide, myristoylated

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated include:

Preta et al (2015) Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J 29 1516 PMID: 25550455

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS One 10 e0131430 PMID: 26102354

Kolpak et al (2009) Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. Circ Res 29 10488 PMID: 19710302

Choi et al (2005) Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. PLoS One 97 363 PMID: 16051887


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