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Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
Control Peptide also available.
(Modifications: Gln-1 = Myr-Gln, Pro-10 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966
Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117
Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920
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Keywords: Dynamin inhibitory peptide, myristoylated, Dynamin inhibitory peptide, myristoylated supplier, Cell-permeable, dynamin, inhibitors, inhibits, Dynamin, Epac, GTPases, Mitosis, 1775, Tocris Bioscience
4 Citations for Dynamin inhibitory peptide, myristoylated
Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated include:
Choi et al (2005) Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. PLoS One 97 363 PMID: 16051887
Preta et al (2015) Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J 29 1516 PMID: 25550455
Kolpak et al (2009) Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. Circ Res 29 10488 PMID: 19710302
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS One 10 e0131430 PMID: 26102354
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