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Biological Activity for DSPC
DSPC is a phosphatidylcholine, a type of neutral phospholipid with two saturated long-chains (18:0). Commonly used in the generation of micelles, liposomes, lipid nanoparticles (LNPs) and other types of artificial membranes. DSPC is used in formulation of LNPs for nonviral drug delivery systems.
For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.
Technical Data for DSPC
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DSPC
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||15.8||20 with gentle warming|
Preparing Stock Solutions for DSPC
The following data is based on the product molecular weight 790.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.27 mL||6.33 mL||12.66 mL|
|5 mM||0.25 mL||1.27 mL||2.53 mL|
|10 mM||0.13 mL||0.63 mL||1.27 mL|
|50 mM||0.03 mL||0.13 mL||0.25 mL|
References for DSPC
References are publications that support the biological activity of the product.
Lou et al (2020) Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J.Control Release 325 370 PMID: 32619745
Zhang et al (2020) Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual antifibrotic and anti-inflammatory activities. ACS Nano 14 6305 PMID: 32378877
If you know of a relevant reference for DSPC, please let us know.
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Citations for DSPC
Citations are publications that use Tocris products.
Currently there are no citations for DSPC. Do you know of a great paper that uses DSPC from Tocris? Please let us know.
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