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Description: Neutral phospholipid; component of lipid nanoparticles (LNPs)
Alternative Names: 1,2-DSPC
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphocholine
Purity: ≥95% (HPLC)
Protocols (1)

Biological Activity for DSPC

DSPC is a phosphatidylcholine, a type of neutral phospholipid with two saturated long-chains (18:0). Commonly used in the generation of micelles, liposomes, lipid nanoparticles (LNPs) and other types of artificial membranes. DSPC is used in formulation of LNPs for nonviral drug delivery systems.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Technical Data for DSPC

M. Wt 790.15
Formula C44H88NO8P
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 816-94-4
PubChem ID 94190

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DSPC

Solvent Max Conc. mg/mL Max Conc. mM
chloroform 79.01 100
ethanol 15.8 20 with gentle warming

Preparing Stock Solutions for DSPC

The following data is based on the product molecular weight 790.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.33 mL 12.66 mL
5 mM 0.25 mL 1.27 mL 2.53 mL
10 mM 0.13 mL 0.63 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

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References for DSPC

References are publications that support the biological activity of the product.

Lou et al (2020) Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J.Control Release 325 370 PMID: 32619745

Zhang et al (2020) Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual antifibrotic and anti-inflammatory activities. ACS Nano 14 6305 PMID: 32378877

If you know of a relevant reference for DSPC, please let us know.

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Citations for DSPC

Citations are publications that use Tocris products.

Currently there are no citations for DSPC. Do you know of a great paper that uses DSPC from Tocris? Please let us know.

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Protocols for DSPC

The following protocol features additional information for the use of DSPC (Cat. No. 7943).