You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for DS2
DS2 is a positive allosteric modulator of GABAA receptors. Potentiates GABA-evoked currents mediated by α4β3δ receptors (EC50 = 142 nM, in vitro). Displays complex selectivity profile, with selectivity for δ-containing receptors (α4/6βxδ > α1βxδ >> γ2 > α4β3 GABAA receptors). Enhances tonic currents of thalamocortical neurons in wild-type mice.
Compound Libraries for DS2
Technical Data for DS2
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DS2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DS2
The following data is based on the product molecular weight 353.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.65 mL||28.26 mL||56.52 mL|
|2.5 mM||1.13 mL||5.65 mL||11.3 mL|
|5 mM||0.57 mL||2.83 mL||5.65 mL|
|25 mM||0.11 mL||0.57 mL||1.13 mL|
References for DS2
References are publications that support the biological activity of the product.
Wafford et al (2009) Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus. Neuropharmacology 56 182 PMID: 18762200
Jensen et al (2013) A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors. Br.J.Pharmacol. 168 1118 PMID: 23061935
Ahring et al (2016) A pharmacological assessment of agonists and modulators at α4β2γ2 and α4β2δ GABAA receptors: The challenge in comparing apples with oranges. Pharmacol.Res. 111 563 PMID: 27178730
If you know of a relevant reference for DS2, please let us know.
View Related Products by Product Action
Keywords: DS2, DS2 supplier, Positive, allosteric, modulators, delta, GABAA, receptors, PAM, Receptors, 3679, Tocris Bioscience
8 Citations for DS2
Citations are publications that use Tocris products. Selected citations for DS2 include:
Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem Pharmacol 150 305 PMID: 29454619
Tong et al (2015) Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. J Neurosci 35 16142 PMID: 26658866
Hammer et al (2015) Functional characterization of the 1,5-benzodiazepine clo. and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes. PLoS One 10 e0120239 PMID: 25798598
Shu et al (2012) Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. Br J Pharmacol 165 2228 PMID: 21950777
Mirheydari et al (2014) Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site. Neurochem Res 39 1057 PMID: 24072672
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. Nat Methods 34 10219 PMID: 25080584
Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci 36 607 PMID: 26758848
Mennerick et al (2014) Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function. Psychopharmacology (Berl) 231 3493 PMID: 24553581
Do you know of a great paper that uses DS2 from Tocris? Please let us know.
Reviews for DS2
There are currently no reviews for this product. Be the first to review DS2 and earn rewards!
Have you used DS2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.