DS2

Pricing Availability Delivery Time Qty
Cat.No. 3679 - DS2 | C18H12ClN3OS | CAS No. 374084-31-8
Description: Positive allosteric modulator of δ-containing GABAA receptors
Chemical Name: 4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Positive allosteric modulator of δ-subunit containing GABAA receptors (EC50 = 142 nM for α4β3δ receptors). Displays no effects on GABA responses mediated by α4β3γ2 and α1β3γ2 receptors.

Compound Libraries

DS2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 353.83
Formula C18H12ClN3OS
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 374084-31-8
PubChem ID 979718
InChI Key AZKMWHRDICVYEI-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(Cl)C=C4)NC2=C(C3=CC=CS3)N=C1C=CC=CN12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.69 50

Preparing Stock Solutions

The following data is based on the product molecular weight 353.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.13 mL 28.26 mL
5 mM 0.57 mL 2.83 mL 5.65 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wafford et al (2009) Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus. Neuropharmacology 56 182 PMID: 18762200


If you know of a relevant reference for DS2, please let us know.

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Keywords: Positive allosteric modulators delta GABAA receptors GABAA Receptors

3 Citations for DS2

Citations are publications that use Tocris products. Selected citations for DS2 include:

Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci 36 607 PMID: 26758848

Mirheydari et al (2014) Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site. Neurochem Res 39 1057 PMID: 24072672

Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. Nat Methods 34 10219 PMID: 25080584


Do you know of a great paper that uses DS2 from Tocris? If so please let us know.

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Pathways for DS2

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