Droperidol

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Cat.No. 5858 - Droperidol | C22H22FN3O2 | CAS No. 548-73-2
Description: D2 receptor antagonist
Chemical Name: 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

D2 receptor antagonist. Also exhibits affinity for 5-HT, α-adrenergic and histamine receptors,and hERG channels. Antipsychotic and antiemetic.

Technical Data

M. Wt 379.43
Formula C22H22FN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 548-73-2
PubChem ID 3168
InChI Key RMEDXOLNCUSCGS-UHFFFAOYSA-N
Smiles FC1=CC=C(C(CCCN2CCC(N3C(NC4=C3C=CC=C4)=O)=CC2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 379.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Peroutka and Synder (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am.J.Psychiatry 137 1518 PMID: 6108081

Rajamani et al (2005) A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorg.Med.Chem.Lett. 15 1737 PMID: 15745831


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Keywords: dopamine receptors D2 antagonists antipsychotics antiemetics herg channels D2 Receptors

Citations for Droperidol

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Literature in this Area

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Pathways for Droperidol

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