Discontinued Product

Droperidol (Cat. No. 5858) has been withdrawn from sale for commercial reasons.
Description: D2 antagonist
Chemical Name: 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for Droperidol

Droperidol is a D2 receptor antagonist. Also exhibits affinity for 5-HT, α-adrenergic and histamine receptors,and hERG channels. Antipsychotic and antiemetic.

Technical Data for Droperidol

M. Wt 379.43
Formula C22H22FN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 548-73-2
PubChem ID 3168
Smiles FC1=CC=C(C(CCCN2CCC(N3C(NC4=C3C=CC=C4)=O)=CC2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Droperidol

References are publications that support the biological activity of the product.

Peroutka and Synder (1980) Relationship of neuroleptic drug effects at brain DA, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am.J.Psychiatry 137 1518 PMID: 6108081

Rajamani et al (2005) A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorg.Med.Chem.Lett. 15 1737 PMID: 15745831

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Keywords: Droperidol, Droperidol supplier, dopamine, receptors, D2, antagonists, antipsychotics, antiemetics, herg, channels, Receptors, Voltage-Gated, Potassium, Channels, 5858, Tocris Bioscience

Citations for Droperidol

Citations are publications that use Tocris products.

Currently there are no citations for Droperidol.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.