Discontinued Product

DPNI-caged-GABA (Cat. No. 2991) has been withdrawn from sale for commercial reasons.
Description: Nitroindoline-caged GABA
Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for DPNI-caged-GABA

Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.

Licensing Information

Sold under licence from the Medical Research Council.

Technical Data for DPNI-caged-GABA

M. Wt 499.3
Formula C15H23N3O12P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 927866-58-8
PubChem ID 15953814
Smiles O=C(CCCN)N2C1=C([N+]([O-])=O)C=CC(OC(COP(O)(O)=O)COP(O)(O)=O)=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for DPNI-caged-GABA

Certificate of Analysis / Product Datasheet
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References for DPNI-caged-GABA

References are publications that support the biological activity of the product.

Wieboldt et al (1994) Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region. Biochemistry 33 1526 PMID: 8312272

Trigo et al (2009) Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J.Neurosci.Meths. 181 159 PMID: 19422852

Trigo (2010) Presynaptic miniature GABAergic currents in developing interneurons. Neuron 66 235 PMID: 20435000

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Keywords: DPNI-caged-GABA, DPNI-caged-GABA supplier, nitroindoline, reduces, peak, GABA-evoked, responses, caged, compounds, Caged, GABA, Compounds, GABAA, Receptors, 2991, Tocris Bioscience

2 Citations for DPNI-caged-GABA

Citations are publications that use Tocris products. Selected citations for DPNI-caged-GABA include:

Nunez-Parra et al (2013) Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination. PLoS One 110 14777 PMID: 23959889

Spoljaric et al (2019) KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep 26 1073 PMID: 30699338

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.