DPNI-caged-GABA

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Cat.No. 2991 - DPNI-caged-GABA | C15H23N3O12P2 | CAS No. 927866-58-8
Description: Nitroindoline-caged GABA
Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.

Licensing Information

Sold under licence from the Medical Research Council.

Technical Data

M. Wt 499.3
Formula C15H23N3O12P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 927866-58-8
PubChem ID 15953814
InChI Key QLCHBTSDKGMLRN-UHFFFAOYSA-N
Smiles O=C(CCCN)N2C1=C([N+]([O-])=O)C=CC(OC(COP(O)(O)=O)COP(O)(O)=O)=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1 2mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 499.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.03 mL
5 mM 0.4 mL 2 mL 4.01 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wieboldt et al (1994) Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region. Biochemistry 33 1526 PMID: 8312272

Trigo et al (2009) Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J.Neurosci.Meths. 181 159 PMID: 19422852

Trigo (2010) Presynaptic miniature GABAergic currents in developing interneurons. Neuron 66 235 PMID: 20435000


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Keywords: DPNI-caged-GABA, supplier, nitroindoline, reduces, peak, GABA-evoked, responses, caged, compounds, GABAA, Receptors, Tocris Bioscience

1 Citation for DPNI-caged-GABA

Citations are publications that use Tocris products. Selected citations for DPNI-caged-GABA include:

Nunez-Parra et al (2013) Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination. PLoS One 110 14777 PMID: 23959889


Do you know of a great paper that uses DPNI-caged-GABA from Tocris? If so please let us know.

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