Pricing Availability   Qty
Description: Endogenous agonist
Chemical Name: γ-Aminobutyric acid
Citations (19)
Literature (2)

Biological Activity for GABA

GABA is a GABA receptor agonist and endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).

Technical Data for GABA

M. Wt 103.12
Formula C4H9NO2
Storage Store at RT
CAS Number 56-12-2
PubChem ID 119
Smiles NCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GABA

Solvent Max Conc. mg/mL Max Conc. mM
water 10.31 100

Preparing Stock Solutions for GABA

The following data is based on the product molecular weight 103.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.7 mL 48.49 mL 96.97 mL
5 mM 1.94 mL 9.7 mL 19.39 mL
10 mM 0.97 mL 4.85 mL 9.7 mL
50 mM 0.19 mL 0.97 mL 1.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for GABA

Certificate of Analysis / Product Datasheet
Select another batch:

References for GABA

References are publications that support the biological activity of the product.

Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222 PMID: 4393081

Decavel and van den Pol (1990) GABA: a dominant transmitter in the hypothalamus. J.Comp.Neurol. 302 1019 PMID: 2081813

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Malcangio and Bowery (1996) GABA and its receptors in the spinal cord. TiPS 17 457 PMID: 9014500

If you know of a relevant reference for GABA, please let us know.

View Related Products by Product Action

View all GABAA Receptor Agonists

Keywords: GABA, GABA supplier, Endogenous, agonists, GABAA, Receptors, GABAC, GABAB, IAA, inhibitory, amino, acid, gamma-Aminobutyric, γ-aminobutyric, g-Aminobutyric, GABAA-rho, 0344, Tocris Bioscience

19 Citations for GABA

Citations are publications that use Tocris products. Selected citations for GABA include:

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996

Sciolino et al (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behav Brain Res 233 191 PMID: 22580167

Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874 PMID: 22590629

Rundfeldt (2000) Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung 50 1063 PMID: 11190770

Bali et al (2019) Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. Sci Rep 9 9324 PMID: 31249369

Nakano et al (2019) Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep 27 860 PMID: 30995482

David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341 PMID: 28300633

Lecat-Guillet et al (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129

Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458

Garcia et al (2019) Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci 13 669 PMID: 31316341

Gascon et al (2006) GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci 26 12956 PMID: 17167085

Diógenes et al (2014) Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex 24 67 PMID: 22997174

Won et al (2011) Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. J Neurophysiol 105 442 PMID: 20962070

Brown et al (2016) γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem 291 13926 PMID: 27129275

Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240 PMID: 27687783

Fuchs et al (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Evid Based Complement Alternat Med 38 3146 PMID: 23909897

Zhu (2018) Structure of a human synaptic GABAA receptor. Nature 559 67 PMID: 29950725

Atherton et al (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586 5679 PMID: 18832425

Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Eur J Neurosci 3 282 PMID: 25254342

Do you know of a great paper that uses GABA from Tocris? Please let us know.

Reviews for GABA

There are currently no reviews for this product. Be the first to review GABA and earn rewards!

Have you used GABA?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.