GABA

Pricing Availability Delivery Time Qty
Cat.No. 0344 - GABA | C4H9NO2 | CAS No. 56-12-2
Description: Endogenous agonist
Chemical Name: γ-Aminobutyric acid
Datasheet
Citations (9)
Literature

Biological Activity

Endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).

Technical Data

M. Wt 103.12
Formula C4H9NO2
Storage Store at RT
CAS Number 56-12-2
PubChem ID 119
InChI Key BTCSSZJGUNDROE-UHFFFAOYSA-N
Smiles NCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 103.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.7 mL 48.49 mL 96.97 mL
5 mM 1.94 mL 9.7 mL 19.39 mL
10 mM 0.97 mL 4.85 mL 9.7 mL
50 mM 0.19 mL 0.97 mL 1.94 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222 PMID: 4393081

Decavel and van den Pol (1990) GABA: a dominant transmitter in the hypothalamus. J.Comp.Neurol. 302 1019 PMID: 2081813

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Malcangio and Bowery (1996) GABA and its receptors in the spinal cord. TiPS 17 457 PMID: 9014500


If you know of a relevant reference for GABA, please let us know.

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9 Citations for GABA

Citations are publications that use Tocris products. Selected citations for GABA include:

Atherton et al (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586 5679 PMID: 18832425

David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341 PMID: 28300633

Lecat-Guillet et al (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129

Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240 PMID: 27687783

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996

Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Eur J Neurosci 3 282 PMID: 25254342

Fuchs et al (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Evid Based Complement Alternat Med 38 3146 PMID: 23909897

Sciolino et al (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behav Brain Res 233 191 PMID: 22580167

Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874 PMID: 22590629


Do you know of a great paper that uses GABA from Tocris? If so please let us know.

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Reviews

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Protocols

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