GABA

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Cat.No. 0344 - GABA | C4H9NO2 | CAS No. 56-12-2
Description: Endogenous agonist
Chemical Name: γ-Aminobutyric acid
Datasheet
Citations (17)
Reviews
Literature

Biological Activity

Endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).

Technical Data

M. Wt 103.12
Formula C4H9NO2
Storage Store at RT
CAS Number 56-12-2
PubChem ID 119
InChI Key BTCSSZJGUNDROE-UHFFFAOYSA-N
Smiles NCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 103.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.7 mL 48.49 mL 96.97 mL
5 mM 1.94 mL 9.7 mL 19.39 mL
10 mM 0.97 mL 4.85 mL 9.7 mL
50 mM 0.19 mL 0.97 mL 1.94 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222 PMID: 4393081

Decavel and van den Pol (1990) GABA: a dominant transmitter in the hypothalamus. J.Comp.Neurol. 302 1019 PMID: 2081813

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Malcangio and Bowery (1996) GABA and its receptors in the spinal cord. TiPS 17 457 PMID: 9014500


If you know of a relevant reference for GABA, please let us know.

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Keywords: GABA, GABA supplier, Endogenous, agonists, GABAA, Receptors, GABAC, GABAB, IAA, inhibitory, amino, acid, gamma-Aminobutyric, γ-aminobutyric, g-Aminobutyric, GABAA-rho, 0344, Tocris Bioscience

17 Citations for GABA

Citations are publications that use Tocris products. Selected citations for GABA include:

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996

Atherton et al (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586 5679 PMID: 18832425

Bali et al (2019) Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. Sci Rep 9 9324 PMID: 31249369

Fuchs et al (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Evid Based Complement Alternat Med 38 3146 PMID: 23909897

Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240 PMID: 27687783

Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458

Gascon et al (2006) GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci 26 12956 PMID: 17167085

Zhu (2018) Structure of a human synaptic GABAA receptor. Nature 559 67 PMID: 29950725

Brown et al (2016) γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem 291 13926 PMID: 27129275

Won et al (2011) Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. J Neurophysiol 105 442 PMID: 20962070

David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341 PMID: 28300633

Lecat-Guillet et al (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129

Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Eur J Neurosci 3 282 PMID: 25254342

Rundfeldt (2000) Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung 50 1063 PMID: 11190770

Diógenes et al (2014) Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex 24 67 PMID: 22997174

Sciolino et al (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behav Brain Res 233 191 PMID: 22580167

Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874 PMID: 22590629


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Reviews for GABA

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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