Endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 103.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||9.7 mL||48.49 mL||96.97 mL|
|5 mM||1.94 mL||9.7 mL||19.39 mL|
|10 mM||0.97 mL||4.85 mL||9.7 mL|
|50 mM||0.19 mL||0.97 mL||1.94 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222 PMID: 4393081
Decavel and van den Pol (1990) GABA: a dominant transmitter in the hypothalamus. J.Comp.Neurol. 302 1019 PMID: 2081813
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
Malcangio and Bowery (1996) GABA and its receptors in the spinal cord. TiPS 17 457 PMID: 9014500
If you know of a relevant reference for GABA, please let us know.
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9 Citations for GABA
Citations are publications that use Tocris products. Selected citations for GABA include:
David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341 PMID: 28300633
Lecat-Guillet et al (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129
Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240 PMID: 27687783
Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996
Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Eur J Neurosci 3 282 PMID: 25254342
Fuchs et al (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Evid Based Complement Alternat Med 38 3146 PMID: 23909897
Sciolino et al (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behav Brain Res 233 191 PMID: 22580167
Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874 PMID: 22590629
Atherton et al (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586 5679 PMID: 18832425
Do you know of a great paper that uses GABA from Tocris? If so please let us know.
Literature in this Area
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.