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Biological Activity for GABA
GABA is a GABA receptor agonist and endogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).
Technical Data for GABA
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GABA
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GABA
The following data is based on the product molecular weight 103.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||9.7 mL||48.49 mL||96.97 mL|
|5 mM||1.94 mL||9.7 mL||19.39 mL|
|10 mM||0.97 mL||4.85 mL||9.7 mL|
|50 mM||0.19 mL||0.97 mL||1.94 mL|
References for GABA
References are publications that support the biological activity of the product.
Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222 PMID: 4393081
Decavel and van den Pol (1990) GABA: a dominant transmitter in the hypothalamus. J.Comp.Neurol. 302 1019 PMID: 2081813
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
Malcangio and Bowery (1996) GABA and its receptors in the spinal cord. TiPS 17 457 PMID: 9014500
If you know of a relevant reference for GABA, please let us know.
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Keywords: GABA, GABA supplier, Endogenous, agonists, GABAA, Receptors, GABAC, GABAB, IAA, inhibitory, amino, acid, gamma-Aminobutyric, γ-aminobutyric, g-Aminobutyric, GABAA-rho, 0344, Tocris Bioscience
19 Citations for GABA
Citations are publications that use Tocris products. Selected citations for GABA include:
Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240 PMID: 27687783
Diógenes et al (2014) Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex 24 67 PMID: 22997174
Sciolino et al (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behav Brain Res 233 191 PMID: 22580167
Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874 PMID: 22590629
Bali et al (2019) Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. Sci Rep 9 9324 PMID: 31249369
Brown et al (2016) γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem 291 13926 PMID: 27129275
Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458
Nakano et al (2019) Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep 27 860 PMID: 30995482
David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341 PMID: 28300633
Lecat-Guillet et al (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 360 PMID: 28286129
Gascon et al (2006) GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci 26 12956 PMID: 17167085
Garcia et al (2019) Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci 13 669 PMID: 31316341
Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Eur J Neurosci 3 282 PMID: 25254342
Won et al (2011) Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons. J Neurophysiol 105 442 PMID: 20962070
Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996
Rundfeldt (2000) Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung 50 1063 PMID: 11190770
Fuchs et al (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Evid Based Complement Alternat Med 38 3146 PMID: 23909897
Atherton et al (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586 5679 PMID: 18832425
Zhu (2018) Structure of a human synaptic GABAA receptor. Nature 559 67 PMID: 29950725
Do you know of a great paper that uses GABA from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.