DMP 543

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Cat.No. 2330 - DMP 543 | C26H18F2N2O | CAS No. 160588-45-4
Description: Potent and selective K2P3.1 (TASK-1) channel blocker
Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

K+ channel blocker and acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo.

Compound Libraries

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Technical Data

M. Wt 412.44
Formula C26H18F2N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 160588-45-4
PubChem ID 9887884
InChI Key MUJBUUDUXGDXLW-UHFFFAOYSA-N
Smiles FC1=CC(CC2(CC3=CC(F)=NC=C3)C3=CC=CC=C3C(=O)C3=C2C=CC=C3)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.24 100
ethanol 20.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 412.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.25 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724 PMID: 9580619

Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615 PMID: 9804701


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Keywords: K+ channels blockers potent ACh release enhancer Potent orally active Potassium Channels Non-Selective Acetylcholine Nicotinic Receptors nAChR Muscarinic DMP543 Two-P Potassium Channels

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