DMG-PEG 2000

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Description: PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)
Chemical Name: 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
Purity: ≥90% (HPLC)
Protocols (1)

Biological Activity for DMG-PEG 2000

DMG-PEG 2000 is a PEGylated myristoyl diglyceride consisting of one unbranched PEG 2000 chain and two saturated fatty acid chains (C14:0) covalently attached to a glycerol. DMG-PEG 2000 is commonly used in the formation of lipid nanoparticles (LNPs) and liposomes to prevent serum protein adsorption, nanoparticle aggregation and increase in vivo circulation time. DMG-PEG 2000 is a component of LNPs which can be used for delivery of RNA-based vaccines or mRNA therapeutics.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Technical Data for DMG-PEG 2000

Formula (C2H4O)nC32H62O5
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 160743-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMG-PEG 2000

Solubility Soluble to 10 mg/ml in ethanol and to 10 mg/ml in chloroform

References for DMG-PEG 2000

References are publications that support the biological activity of the product.

Cheng et al (2018) Dendrimer-based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv.Mater. 30 e1805308 PMID: 30368954

Zhang et al (2020) Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing. Sci.Adv. 6 eabc2315 PMID: 32937374

If you know of a relevant reference for DMG-PEG 2000, please let us know.

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Citations for DMG-PEG 2000

Citations are publications that use Tocris products.

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Protocols for DMG-PEG 2000

The following protocol features additional information for the use of DMG-PEG 2000 (Cat. No. 7944).