DMCM hydrochloride

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Cat.No. 3083 - DMCM hydrochloride | C17H18N2O4.HCl | CAS No. 1215833-62-7
Description: Benzodiazepine inverse agonist
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.

Technical Data

M. Wt 350.8
Formula C17H18N2O4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1215833-62-7
PubChem ID 45261899
InChI Key FHCRBVQGMZUJKY-UHFFFAOYSA-N
Smiles CCC1=C(C(OC)=O)N=CC3=C1C2=CC(OC)=C(OC)C=C2N3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.43 100
DMSO 17.54 50

Preparing Stock Solutions

The following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.25 mL 28.51 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117 PMID: 6317396

Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417 PMID: 16297441

Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180


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Keywords: DMCM hydrochloride, DMCM hydrochloride supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, 3083, Tocris Bioscience

3 Citations for DMCM hydrochloride

Citations are publications that use Tocris products. Selected citations for DMCM hydrochloride include:

Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219 PMID: 25080584

Nguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131 PMID: 23835499

Alia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823 PMID: 27897203


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Reviews for DMCM hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel

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GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

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Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

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