DMCM hydrochloride

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Cat.No. 3083 - DMCM hydrochloride | C17H18N2O4.HCl | CAS No. 1215833-62-7
Description: Benzodiazepine inverse agonist
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.

Technical Data

M. Wt 350.8
Formula C17H18N2O4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1215833-62-7
PubChem ID 45261899
InChI Key FHCRBVQGMZUJKY-UHFFFAOYSA-N
Smiles CCC1=C(C(OC)=O)N=CC3=C1C2=CC(OC)=C(OC)C=C2N3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.54 50
water 31.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.25 mL 28.51 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117 PMID: 6317396

Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417 PMID: 16297441

Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180 PMID:


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Keywords: DMCM hydrochloride, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

3 Citations for DMCM hydrochloride

Citations are publications that use Tocris products. Selected citations for DMCM hydrochloride include:

Alia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823 PMID: 27897203

Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219 PMID: 25080584

Nguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131 PMID: 23835499


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Pathways for DMCM hydrochloride

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