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Submit ReviewDMCM hydrochloride
Description: Benzodiazepine inverse agonist
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for DMCM hydrochloride
DMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
Compound Libraries for DMCM hydrochloride
DMCM hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for DMCM hydrochloride
| M. Wt | 350.8 |
| Formula | C17H18N2O4.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1215833-62-7 |
| PubChem ID | 45261899 |
| InChI Key | FHCRBVQGMZUJKY-UHFFFAOYSA-N |
| Smiles | CCC1=C(C(OC)=O)N=CC3=C1C2=CC(OC)=C(OC)C=C2N3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DMCM hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.43 | 100 | |
| DMSO | 7.02 | 20 |
Preparing Stock Solutions for DMCM hydrochloride
The following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.25 mL | 28.51 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.7 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets for DMCM hydrochloride
References for DMCM hydrochloride
References are publications that support the biological activity of the product.
Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117 PMID: 6317396
Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417 PMID: 16297441
Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180 PMID: 11205417
If you know of a relevant reference for DMCM hydrochloride, please let us know.
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Keywords: DMCM hydrochloride, DMCM hydrochloride supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, 3083, Tocris Bioscience
3 Citations for DMCM hydrochloride
Citations are publications that use Tocris products. Selected citations for DMCM hydrochloride include:
Alia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823 PMID: 27897203
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219 PMID: 25080584
Nguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131 PMID: 23835499
Do you know of a great paper that uses DMCM hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.