Pricing Availability   Qty
Description: Component of lipid nanoparticles (LNPs); ionizable cationic lipid
Chemical Name: (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
Purity: ≥95% (HPLC)
Protocols (1)

Biological Activity for DLin-MC3-DMA

DLin-MC3-DMA is an ionizable cationic lipid (pKa = 6.44), used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for delivering cargos such as oligonucleotides into living cells. DLin-MC3-DMA can protect negatively charged cargos and facilitate their cytosolic transport.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Technical Data for DLin-MC3-DMA

M. Wt 642.09
Formula C43H79NO2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1224606-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DLin-MC3-DMA

Solubility Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL)

References for DLin-MC3-DMA

References are publications that support the biological activity of the product.

Han et al (2021) An ionizable lipid toolbox for RNA delivery. Nat.Commun 12 7233 PMID: 34903741

Semple et al (2010) Rational design of cationic lipids for siRNA delivery. Nat.Biotechnol 28 172 PMID: 20081866

Jayaraman et al (2012) Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew.Chem.Int.Ed.Engl 51 8529 PMID: 22782619

If you know of a relevant reference for DLin-MC3-DMA, please let us know.

Keywords: DLin-MC3-DMA, DLin-MC3-DMA supplier, DLinMC3DMA, unsaturated, ionizable, cationic, lipid, nanoparticles, LNP, cargo, delivery, cytosolic, transport, Biochemicals, and, Molecular, Biology, Lipid, Nanoparticles, 7946, Tocris Bioscience

Citations for DLin-MC3-DMA

Citations are publications that use Tocris products.

Currently there are no citations for DLin-MC3-DMA. Do you know of a great paper that uses DLin-MC3-DMA from Tocris? Please let us know.

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Protocols for DLin-MC3-DMA

The following protocol features additional information for the use of DLin-MC3-DMA (Cat. No. 7946).