DL-AP3

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Cat.No. 0125 - DL-AP3 | C3H8NO5P | CAS No. 20263-06-3
Description: Group I mGlu antagonist
Chemical Name: DL-2-Amino-3-phosphonopropionic acid
Datasheet
Citations (1)
Literature

Biological Activity

Competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.

Technical Data

M. Wt 169.07
Formula C3H8NO5P
Storage Store at RT
CAS Number 20263-06-3
PubChem ID 3857
InChI Key LBTABPSJONFLPO-UHFFFAOYSA-N
Smiles NC(CP(O)(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 16.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 169.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.91 mL 29.57 mL 59.15 mL
5 mM 1.18 mL 5.91 mL 11.83 mL
10 mM 0.59 mL 2.96 mL 5.91 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024

Hawkinson et al (1996) The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 307 219 PMID: 8832224

Saugstad et al (1995) L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes. Eur.J.Pharmacol. 289 395 PMID: 7621916


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View Related Products by Product Action

View all Glutamate (Metabotropic) Group I Receptor Antagonists

Keywords: DL-AP3, supplier, Phosphoserine, phosphatase, inhibitors, inhibits, Group, I, mGlur, antagonists, Protein, Ser/Thr, Phosphatases, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

1 Citation for DL-AP3

Citations are publications that use Tocris products. Selected citations for DL-AP3 include:

Vance et al (2015) PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci 35 776 PMID: 25589770


Do you know of a great paper that uses DL-AP3 from Tocris? If so please let us know.

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