DL-AP3

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Cat.No. 0125 - DL-AP3 | C3H8NO5P | CAS No. 5652-28-8
Description: Group I mGlu antagonist; also phosphoserine phosphatase inhibitor
Chemical Name: DL-2-Amino-3-phosphonopropionic acid
Datasheet
Citations (1)
Reviews
Literature (10)

Biological Activity

Competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.

Technical Data

M. Wt 169.07
Formula C3H8NO5P
Storage Store at RT
CAS Number 5652-28-8
PubChem ID 3857
InChI Key LBTABPSJONFLPO-UHFFFAOYSA-N
Smiles NC(CP(O)(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 16.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 169.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.91 mL 29.57 mL 59.15 mL
5 mM 1.18 mL 5.91 mL 11.83 mL
10 mM 0.59 mL 2.96 mL 5.91 mL
50 mM 0.12 mL 0.59 mL 1.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024

Hawkinson et al (1996) The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 307 219 PMID: 8832224

Saugstad et al (1995) L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes. Eur.J.Pharmacol. 289 395 PMID: 7621916


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View Related Products by Product Action

View all Glutamate (Metabotropic) Group I Receptor Antagonists

Keywords: DL-AP3, DL-AP3 supplier, Phosphoserine, phosphatase, inhibitors, inhibits, Group, I, mGlur, antagonists, Protein, Ser/Thr, Phosphatases, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, 20263-06-3, (Metabotropic), 0125, Tocris Bioscience

1 Citation for DL-AP3

Citations are publications that use Tocris products. Selected citations for DL-AP3 include:

Vance et al (2015) PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci 35 776 PMID: 25589770


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Reviews for DL-AP3

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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