Diltiazem hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0685 - Diltiazem hydrochloride | C22H26N2O4S.HCl | CAS No. 33286-22-5
Description: Ca2+ channel blocker (L-type)
Chemical Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.

Compound Libraries

Diltiazem hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.98
Formula C22H26N2O4S.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 33286-22-5
PubChem ID 62920
Smiles [H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.1 100
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 450.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.09 mL 22.17 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Dagani et al (1989) Effects of diltiazem on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379 PMID: 2795006

Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem. Br.J.Pharmacol. 118 1301 PMID: 8818357

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88 PMID: 8574653

Kraus et al (1998) Molecular mechanisms of diltiazem interaction with L-type Ca2+ channels. J.Biol.Chem. 273 27205 PMID: 9765241

Merck Index 12 3247 PMID:

If you know of a relevant reference for Diltiazem hydrochloride, please let us know.

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2 Citations for Diltiazem hydrochloride

Citations are publications that use Tocris products. Selected citations for Diltiazem hydrochloride include:

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. PLoS One 35 5664 PMID: 25855180

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Brain Behav 10 e0121634 PMID: 25803863

Do you know of a great paper that uses Diltiazem hydrochloride from Tocris? If so please let us know.

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