Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 450.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.22 mL||11.09 mL||22.17 mL|
|5 mM||0.44 mL||2.22 mL||4.43 mL|
|10 mM||0.22 mL||1.11 mL||2.22 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Dagani et al (1989) Effects of diltiazem on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379 PMID: 2795006
Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem. Br.J.Pharmacol. 118 1301 PMID: 8818357
Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88 PMID: 8574653
Kraus et al (1998) Molecular mechanisms of diltiazem interaction with L-type Ca2+ channels. J.Biol.Chem. 273 27205 PMID: 9765241
If you know of a relevant reference for Diltiazem hydrochloride, please let us know.
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Keywords: Ca2+ channel blockers L-type Calcium CaV Channels voltage-gated voltage-dependent anti-hypertensive cardioprotective Voltage-gated Calcium Channels
2 Citations for Diltiazem hydrochloride
Citations are publications that use Tocris products. Selected citations for Diltiazem hydrochloride include:
Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. PLoS One 35 5664 PMID: 25855180
Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Brain Behav 10 e0121634 PMID: 25803863
Do you know of a great paper that uses Diltiazem hydrochloride from Tocris? If so please let us know.
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