Diltiazem hydrochloride

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Cat.No. 0685 - Diltiazem hydrochloride | C22H26N2O4S.HCl | CAS No. 33286-22-5
Description: CaV1.x blocker
Chemical Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (3)

Biological Activity

Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.

Compound Libraries

Diltiazem hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.98
Formula C22H26N2O4S.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 33286-22-5
PubChem ID 62920
InChI Key HDRXZJPWHTXQRI-BHDTVMLSSA-N
Smiles [H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100
DMSO 45.1 100

Preparing Stock Solutions

The following data is based on the product molecular weight 450.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.09 mL 22.17 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Dagani et al (1989) Effects of dilt. on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379 PMID: 2795006

Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 118 1301 PMID: 8818357

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 695 88 PMID: 8574653

Kraus et al (1998) Molecular mechanisms of dilt. interaction with L-type Ca2+ channels. J.Biol.Chem. 273 27205 PMID: 9765241

Merck Index 12 3247


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View Related Products by Product Action

View all CaV1.x Channel (L-type) Blockers

Keywords: Diltiazem hydrochloride, Diltiazem hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, anti-hypertensive, cardioprotective, Cav1.x, 0685, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Diltiazem hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

5 Citations for Diltiazem hydrochloride

Citations are publications that use Tocris products. Selected citations for Diltiazem hydrochloride include:

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. PLoS One 35 5664 PMID: 25855180

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Brain Behav 10 e0121634 PMID: 25803863

Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ 5 e3113 PMID: 28382232

Lobeck et al (2016) Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes. Virology 499 185 PMID: 27668997


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Literature in this Area

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