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Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 450.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.22 mL||11.09 mL||22.17 mL|
|5 mM||0.44 mL||2.22 mL||4.43 mL|
|10 mM||0.22 mL||1.11 mL||2.22 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Dagani et al (1989) Effects of dilt. on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 53 1379 PMID: 2795006
Gandia et al (1996) Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 118 1301 PMID: 8818357
Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 695 88 PMID: 8574653
Kraus et al (1998) Molecular mechanisms of dilt. interaction with L-type Ca2+ channels. J.Biol.Chem. 273 27205 PMID: 9765241
Merck Index 12 3247
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Keywords: Diltiazem hydrochloride, Diltiazem hydrochloride supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, anti-hypertensive, cardioprotective, Cav1.x, 0685, Tocris Bioscience
5 Citations for Diltiazem hydrochloride
Citations are publications that use Tocris products. Selected citations for Diltiazem hydrochloride include:
Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. PLoS One 35 5664 PMID: 25855180
Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Brain Behav 10 e0121634 PMID: 25803863
Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ 5 e3113 PMID: 28382232
Lobeck et al (2016) Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes. Virology 499 185 PMID: 27668997
Begam et al (2018) DTZ improves contractile properties of skeletal muscle in dysferlin-deficient BLAJ mice, but does not reduce contraction-induced muscle damage. Physiol Rep 6 e13727 PMID: 29890050
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Literature in this Area
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