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Submit ReviewDiazepam
Description: Acts at the benzodiazepine modulatory site
Alternative Names: Ro 5-2807
Chemical Name: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
Purity: ≥98% (HPLC)
Biological Activity
Ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Technical Data
| M. Wt | 284.74 |
| Formula | C16H13ClN2O |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 439-14-5 |
| PubChem ID | 3016 |
| InChI Key | AAOVKJBEBIDNHE-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N(C)C(CN=C2C3=CC=CC=C3)=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.47 | 100 | |
| ethanol | 7.12 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 284.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.56 mL | 35.12 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.02 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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References
References are publications that support the biological activity of the product.
Sieghart et al (1994) Pharmacology of benzodiazepine receptors: an update. J.Psychiat.Neurosci. 19 24
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Keywords: Diazepam, Diazepam supplier, Acts, benzodiazepine, modulatory, site, GABAA, Receptors, Ro52807, Ro, 5-2807, 2805, Tocris Bioscience
8 Citations for Diazepam
Citations are publications that use Tocris products. Selected citations for Diazepam include:
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. PLoS One 40 766 PMID: 25249058
Brodnik et al (2018) Local GABAA receptor mediated suppression of DA release within the nucleus accumbens. ACS Chem Neurosci 17 1978 PMID: 30253088
Zhu (2018) Structure of a human synaptic GABAA receptor. Nature 559 67 PMID: 29950727
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
Huang et al (2010) A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure. J Neurosci 30 16636 PMID: 21148002
Pytka et al (2015) Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT?A and 5-HT? Antagonists in Animal Models. PLoS One 10 e0142499 PMID: 26554929
Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458
Ufuk et al (2015) In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. Pharm Res 32 3937 PMID: 26224396
Do you know of a great paper that uses Diazepam from Tocris? Please let us know.
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