Diazepam

Discontinued Product

Diazepam (Cat. No. 2805) has been withdrawn from sale for commercial reasons.
Description: Acts at the benzodiazepine modulatory site
Alternative Names: Ro 5-2807
Chemical Name: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (2)

Biological Activity for Diazepam

Diazepam is a ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.

Technical Data for Diazepam

M. Wt 284.74
Formula C16H13ClN2O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 439-14-5
PubChem ID 3016
InChI Key AAOVKJBEBIDNHE-UHFFFAOYSA-N
Smiles ClC1=CC=C(N(C)C(CN=C2C3=CC=CC=C3)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Diazepam

Certificate of Analysis / Product Datasheet
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References for Diazepam

References are publications that support the biological activity of the product.

Sieghart et al (1994) Pharmacology of benzodiazepine receptors: an update. J.Psychiat.Neurosci. 19 24

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Keywords: Diazepam, Diazepam supplier, Acts, benzodiazepine, modulatory, site, GABAA, Receptors, Ro52807, Ro, 5-2807, 2805, Tocris Bioscience

8 Citations for Diazepam

Citations are publications that use Tocris products. Selected citations for Diazepam include:

Brodnik et al (2018) Local GABAA receptor mediated suppression of DA release within the nucleus accumbens. ACS Chem Neurosci 17 1978 PMID: 30253088

Zhu (2018) Structure of a human synaptic GABAA receptor. Nature 559 67 PMID: 29950727

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. PLoS One 40 766 PMID: 25249058

Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458


Reviews for Diazepam

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.