Diazepam
Biological Activity
Ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Technical Data
| M. Wt | 284.74 |
| Formula | C16H13ClN2O |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 439-14-5 |
| PubChem ID | 3016 |
| InChI Key | AAOVKJBEBIDNHE-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N(C)C(CN=C2C3=CC=CC=C3)=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.47 | 100 | |
| ethanol | 7.12 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 284.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.56 mL | 35.12 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.02 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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References
References are publications that support the products' biological activity.
Sieghart et al (1994) Pharmacology of benzodiazepine receptors: an update. J.Psychiat.Neurosci. 19 24 PMID:
If you know of a relevant reference for Diazepam, please let us know.
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Keywords: Diazepam, supplier, Acts, benzodiazepine, modulatory, site, GABAA, Receptors, Ro52807, Ro, 5-2807, GABAA, Receptors, Tocris Bioscience
2 Citations for Diazepam
Citations are publications that use Tocris products. Selected citations for Diazepam include:
Ufuk et al (2015) In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. Pharm Res 32 3937 PMID: 26224396
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. PLoS One 40 766 PMID: 25249058
Do you know of a great paper that uses Diazepam from Tocris? If so please let us know.
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