Discontinued Product

DCB (Cat. No. 1952) has been withdrawn from sale for commercial reasons.
Description: Allosteric modulator of mGlu5 receptors
Alternative Names: 3,3'-Dichlorobenzaldazine
Chemical Name: [(3-Chlorophenyl)methylene]hydrazone-3-chlorobenzaldehyde
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for DCB

Allosteric ligand for the metabotropic glutamate receptor mGlu5; displays neutral modulation. Does not affect agonist-stimulated mGlu5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB (Cat. No. 1625) and DMeOB (Cat. No. 1953).

Technical Data for DCB

M. Wt 277.15
Formula C14H10Cl2N2
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 6971-97-7
PubChem ID 9604992
Smiles ClC1=CC(=CC=C1)\N=C\N=C\C1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DCB

References are publications that support the biological activity of the product.

O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 64 731 PMID: 12920211

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Keywords: DCB, DCB supplier, Allosteric, modulators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic, 3,3'-Dichlorobenzaldazine, (Metabotropic), 1952, Tocris Bioscience

Citations for DCB

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Currently there are no citations for DCB.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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