DFB

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Cat.No. 1625 - DFB | C14H10F2N2 | CAS No. 15332-10-2
Description: Allosteric potentiator at mGlu5
Alternative Names: 3,3'-Difluorobenzaldazine
Chemical Name: [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu5 without any effect at other mGlu subtypes (EC50 for potentiation = 2 - 5.3 μM).

Technical Data

M. Wt 244.24
Formula C14H10F2N2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 15332-10-2
PubChem ID 52942441
InChI Key DYNGCIHMNWOBSU-MSQVLRTGSA-K
Smiles FC1=CC(=CC=C1)\C=N\N=C\C1=CC=CC(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.21 50
ethanol 2.44 10

Preparing Stock Solutions

The following data is based on the product molecular weight 244.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.19 mL 40.94 mL 81.89 mL
2.5 mM 1.64 mL 8.19 mL 16.38 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
25 mM 0.16 mL 0.82 mL 1.64 mL

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References

References are publications that support the biological activity of the product.

O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 64 731 PMID: 12920211

Zhang et al (2005) Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J.Pharmacol.Exp.Ther. 315 1212 PMID: 16135701

Williams et al (2002) DFB, an allosteric potentiator of mGluR5 4th International Meeting on Metabotropic Glutamat


If you know of a relevant reference for DFB, please let us know.

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View all Glutamate (Metabotropic) Group I Receptor Modulators

Keywords: DFB, DFB supplier, Allosteric, potentiators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic, 3,3'-Difluorobenzaldazine, (Metabotropic), 1625, Tocris Bioscience

1 Citation for DFB

Citations are publications that use Tocris products. Selected citations for DFB include:

Chen et al (2011) mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. J Biomed Sci 18 19 PMID: 21342491


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