DC 271

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Fluorescent retinoic acid analog; solvochromatic probe
Chemical Name: 4-[2-[1,2,3,4-Tetrahydro-4,4-dimethyl-1-(1-methylethyl)-6-quinolinyl]ethynyl]benzoic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for DC 271

DC 271 is a fluorescent retinoic acid analog (retinoid all-trans-retinoic acid; ATRA) (Kd = 42 nM at cellular retinoid binding protein II (CRABPII)). Solvochromatic probe: fluorescent λex, λem, and quantum yield affected by solvent type. DC 271 can be used in retinoids assays. Activates same genes as endogenous retinoic acid in human keratinocyte cells (HaCaT) when incubated for 72 h at 1 μM. Also elicits cellular responses consistent with those of retinoic acid. Excitation λ = 351, 350, 382 and 378 nm in DMSO, EtOH, DCM and Toluene, respectively; emission λ = 442, 461, 572 and 447 nm in DMSO, EtOH, DCM and Toluene, respectively. Quantum yield = 19.3, 1.14, 71.45, 80.21 % in DMSO, EtOH, DCM and Toluene, respectively.

Technical Data for DC 271

M. Wt 347.46
Formula C23H25NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 198696-03-6
PubChem ID 22971725
Smiles CC(N1CCC(C)(C2=CC(C#CC3=CC=C(C(O)=O)C=C3)=CC=C12)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DC 271

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.37 50
ethanol 3.47 10

Preparing Stock Solutions for DC 271

The following data is based on the product molecular weight 347.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.76 mL 28.78 mL 57.56 mL
2.5 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
25 mM 0.12 mL 0.58 mL 1.15 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for DC 271

References are publications that support the biological activity of the product.

Chisholm et al (2019) Fluorescent retinoic acid analogues as probes for biochemical and intracellular characterization of retinoid signaling pathways. ACS.Chem.Biol. 14 369 PMID: 30707838

Tomlinson et al (2021) Structure-functional relationship of cellular retinoic acid-binding proteins I and II interacting with natural and synthetic ligands. Acta Crystallogr. D Struct. Biol. 77 164 PMID: 33559606

Tomlinson et al (2018) Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins ACS.Med.Chem.Lett. 9 1297

If you know of a relevant reference for DC 271, please let us know.

View Related Products by Product Action

View all Retinoic Acid Receptor Agonists

Keywords: DC 271, DC 271 supplier, DC271, Fluorescent, retinoic, acid, analogs, analogues, cellular, retinoid, binding, protein, II, CRABPII, solvochromatic, Tretinoin, ATRA, Retinoic, Acid, Receptors, Retinoid, X, Receptor, Acid-related, Orphan, ESCs, and, iPSC, Organoids, Probes, Fatty, Binding, Proteins, 6873, Tocris Bioscience

Citations for DC 271

Citations are publications that use Tocris products.

Currently there are no citations for DC 271. Do you know of a great paper that uses DC 271 from Tocris? Please let us know.

Reviews for DC 271

There are currently no reviews for this product. Be the first to review DC 271 and earn rewards!

Have you used DC 271?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.