Dansyl-NECA

Pricing Availability Delivery Time Qty
Cat.No. 5122 - Dansyl-NECA | C30H40N8O6S | CAS No. 219982-12-4
Description: Potent and selective fluorescent adenosine A1 agonist
Chemical Name: 1-Deoxy-1-[6-[[6-[[[5-dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity and selective fluorescent adenosine A1 receptor agonist (Ki values are 27, 3600 and 4300 nM for A1, A3 and A2 receptors, respectively). Permits visualization of A1 receptors in the rat cerebellar cortex.

Technical Data

M. Wt 640.75
Formula C30H40N8O6S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 219982-12-4
PubChem ID 10009321
InChI Key CJDPJPUVKHWZHU-YRIIQKNPSA-N
Smiles CN(C)C1=C2C(C(S(NCCCCCCNC3=NC=NC4=C3N=CN4[C@H]5[C@H](O)[C@H](O)[C@@H]([C@@](NCC)=O)O5)(=O)=O)=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 640.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.56 mL 7.8 mL 15.61 mL
5 mM 0.31 mL 1.56 mL 3.12 mL
10 mM 0.16 mL 0.78 mL 1.56 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Macchia et al (1998) Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. Bioorg. Med. Chem. Lett. 8 3223 PMID: 9873707

Kozma et al (2013) Fluorescent ligands for adenosine receptors. Bioorg. Med. Chem. Lett. 23 26 PMID: 23200243


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Keywords: Dansyl NECA potent selective fluorescent adenosine A1 agonist Adenosine A1 Receptors

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