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Submit ReviewDansyl-NECA
Description: Potent and selective fluorescent adenosine A1 agonist
Chemical Name: 1-Deoxy-1-[6-[[6-[[[5-dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
Purity: ≥99% (HPLC)
Biological Activity
High affinity and selective fluorescent adenosine A1 receptor agonist (Ki values are 27, 3600 and 4300 nM for A1, A3 and A2 receptors, respectively). Permits visualization of A1 receptors in the rat cerebellar cortex.
Technical Data
| M. Wt | 640.75 |
| Formula | C30H40N8O6S |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 219982-12-4 |
| PubChem ID | 10009321 |
| InChI Key | CJDPJPUVKHWZHU-YRIIQKNPSA-N |
| Smiles | CN(C)C1=C2C(C(S(NCCCCCCNC3=NC=NC4=C3N=CN4[C@H]5[C@H](O)[C@H](O)[C@@H]([C@@](NCC)=O)O5)(=O)=O)=CC=C2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 64.08 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 640.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.56 mL | 7.8 mL | 15.61 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 10 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.31 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Macchia et al (1998) Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. Bioorg. Med. Chem. Lett. 8 3223 PMID: 9873707
Kozma et al (2013) Fluorescent ligands for adenosine receptors. Bioorg. Med. Chem. Lett. 23 26 PMID: 23200243
If you know of a relevant reference for Dansyl-NECA, please let us know.
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Keywords: Dansyl-NECA, Dansyl-NECA supplier, Dansyl, NECA, potent, selective, fluorescent, adenosine, A1, agonist, Adenosine, Receptors, Fluorescent, Receptor, Probes, 5122, Tocris Bioscience
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