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Cat.No. 5122 - Dansyl-NECA | C30H40N8O6S | CAS No. 219982-12-4
Description: Potent and selective fluorescent adenosine A1 agonist
Chemical Name: 1-Deoxy-1-[6-[[6-[[[5-dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity

High affinity and selective fluorescent adenosine A1 receptor agonist (Ki values are 27, 3600 and 4300 nM for A1, A3 and A2 receptors, respectively). Permits visualization of A1 receptors in the rat cerebellar cortex.

Technical Data

M. Wt 640.75
Formula C30H40N8O6S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 219982-12-4
PubChem ID 10009321
Smiles CN(C)C1=C2C(C(S(NCCCCCCNC3=NC=NC4=C3N=CN4[C@H]5[C@H](O)[C@H](O)[C@@H]([C@@](NCC)=O)O5)(=O)=O)=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 64.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 640.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.56 mL 7.8 mL 15.61 mL
5 mM 0.31 mL 1.56 mL 3.12 mL
10 mM 0.16 mL 0.78 mL 1.56 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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References are publications that support the biological activity of the product.

Macchia et al (1998) Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. Bioorg. Med. Chem. Lett. 8 3223 PMID: 9873707

Kozma et al (2013) Fluorescent ligands for adenosine receptors. Bioorg. Med. Chem. Lett. 23 26 PMID: 23200243

If you know of a relevant reference for Dansyl-NECA, please let us know.

Keywords: Dansyl-NECA, Dansyl-NECA supplier, Dansyl, NECA, potent, selective, fluorescent, adenosine, A1, agonist, Adenosine, Receptors, Fluorescent, Receptor, Probes, 5122, Tocris Bioscience

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