CW 008

Pricing Availability Delivery Time Qty
Cat.No. 5495 - CW 008 | C21H14F2N6O2 | CAS No. 1134613-19-6
Description: PKA signaling activator; promotes osteogenesis from hMSCs
Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.

Compound Libraries

CW 008 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 420.37
Formula C21H14F2N6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1134613-19-6
PubChem ID 59528098
InChI Key KCIMKTNQCUDTFI-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 420.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.79 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2013) An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J.Cell.Physiol. 228 617 PMID: 22886506


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View all Protein Kinase A Activators

Keywords: CW 008, supplier, CW008, MSC, mesenchymal, stem, cells, protein, kinase, A, PKA, activators, CREB, cAMP, osteogenic, osteogenesis, activators, activates, Protein, Kinase, A, Osteogenic, Stem, Cells, Protein, Kinase, A, Tocris Bioscience

Citations for CW 008

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