CW 008

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Description: PKA signaling activator; promotes osteogenesis from hMSCs
Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for CW 008

CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.

Compound Libraries for CW 008

CW 008 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CW 008

M. Wt 420.37
Formula C21H14F2N6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1134613-19-6
PubChem ID 59528098
Smiles O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CW 008

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.02 50

Preparing Stock Solutions for CW 008

The following data is based on the product molecular weight 420.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.76 mL 23.79 mL 47.58 mL
2.5 mM 0.95 mL 4.76 mL 9.52 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
25 mM 0.1 mL 0.48 mL 0.95 mL

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References for CW 008

References are publications that support the biological activity of the product.

Kim et al (2013) An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J.Cell.Physiol. 228 617 PMID: 22886506

If you know of a relevant reference for CW 008, please let us know.

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Keywords: CW 008, CW 008 supplier, CW008, MSC, mesenchymal, stem, cells, protein, kinase, A, PKA, activators, CREB, cAMP, osteogenic, osteogenesis, activates, Protein, Kinase, Osteogenic, Stem, Cells, 5495, Tocris Bioscience

4 Citations for CW 008

Citations are publications that use Tocris products. Selected citations for CW 008 include:

Xun et al (2023) Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis. Theranostics 13 1247-1263 PMID: 36923539

Karen E et al (2023) Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins. Elife 12 PMID: 36943734

Yong et al (2021) Bisphenol S enhances gap junction intercellular communication in ovarian theca cells. Chemosphere 263 128304 PMID: 33155548

Yong et al (2021) A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Toxicol Mech Methods 31 393-399 PMID: 33784946

Do you know of a great paper that uses CW 008 from Tocris? Please let us know.

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