CW 008

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Cat.No. 5495 - CW 008 | C21H14F2N6O2 | CAS No. 1134613-19-6
Description: PKA signaling activator; promotes osteogenesis from hMSCs
Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for CW 008

CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.

Compound Libraries for CW 008

CW 008 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CW 008

M. Wt 420.37
Formula C21H14F2N6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1134613-19-6
PubChem ID 59528098
Smiles O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CW 008

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.02 50

Preparing Stock Solutions for CW 008

The following data is based on the product molecular weight 420.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.76 mL 23.79 mL 47.58 mL
2.5 mM 0.95 mL 4.76 mL 9.52 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
25 mM 0.1 mL 0.48 mL 0.95 mL

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References for CW 008

References are publications that support the biological activity of the product.

Kim et al (2013) An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J.Cell.Physiol. 228 617 PMID: 22886506

If you know of a relevant reference for CW 008, please let us know.

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Keywords: CW 008, CW 008 supplier, CW008, MSC, mesenchymal, stem, cells, protein, kinase, A, PKA, activators, CREB, cAMP, osteogenic, osteogenesis, activates, Protein, Kinase, Osteogenic, Stem, Cells, 5495, Tocris Bioscience

Citations for CW 008

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Literature in this Area

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