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Submit ReviewCW 008
Description: PKA signaling activator; promotes osteogenesis from hMSCs
Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for CW 008
CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.
Compound Libraries for CW 008
CW 008 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for CW 008
| M. Wt | 420.37 |
| Formula | C21H14F2N6O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1134613-19-6 |
| PubChem ID | 59528098 |
| InChI Key | KCIMKTNQCUDTFI-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CW 008
References for CW 008
References are publications that support the biological activity of the product.
Kim et al (2013) An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J.Cell.Physiol. 228 617 PMID: 22886506
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Keywords: CW 008, CW 008 supplier, CW008, MSC, mesenchymal, stem, cells, protein, kinase, A, PKA, activators, CREB, cAMP, osteogenic, osteogenesis, activates, Protein, Kinase, Osteogenic, Stem, Cells, 5495, Tocris Bioscience
4 Citations for CW 008
Citations are publications that use Tocris products. Selected citations for CW 008 include:
Xun et al (2023) Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis. Theranostics 13 1247-1263 PMID: 36923539
Karen E et al (2023) Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins. Elife 12 PMID: 36943734
Yong et al (2021) Bisphenol S enhances gap junction intercellular communication in ovarian theca cells. Chemosphere 263 128304 PMID: 33155548
Yong et al (2021) A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Toxicol Mech Methods 31 393-399 PMID: 33784946
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