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DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.16 mL||30.79 mL||61.58 mL|
|2.5 mM||1.23 mL||6.16 mL||12.32 mL|
|5 mM||0.62 mL||3.08 mL||6.16 mL|
|25 mM||0.12 mL||0.62 mL||1.23 mL|
References are publications that support the biological activity of the product.
Nishikimi et al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488 PMID: 22520755
Laurin et al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434 PMID: 23592719
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Keywords: CPYPP, CPYPP supplier, DOCK2, DOCK1, DOCK180, DOCK5, Rac1, interaction, inhibitors, inhibits, Rho, 4568, Tocris Bioscience
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