DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.16 mL||30.79 mL||61.58 mL|
|2.5 mM||1.23 mL||6.16 mL||12.32 mL|
|5 mM||0.62 mL||3.08 mL||6.16 mL|
|25 mM||0.12 mL||0.62 mL||1.23 mL|
References are publications that support the biological activity of the product.
Nishikimi et al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488 PMID: 22520755
Laurin et al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434 PMID: 23592719
If you know of a relevant reference for CPYPP, please let us know.
View Related Products by Product Action
Keywords: CPYPP, CPYPP supplier, DOCK2, DOCK1, DOCK180, DOCK5, Rac1, interaction, inhibitors, inhibits, Rho, 4568, Tocris Bioscience
Citations for CPYPP
Citations are publications that use Tocris products.
Currently there are no citations for CPYPP. Do you know of a great paper that uses CPYPP from Tocris? Please let us know.
Reviews for CPYPP
There are currently no reviews for this product. Be the first to review CPYPP and earn rewards!
Have you used CPYPP?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)New
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells