Congo Red

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Cat.No. 5167 - Congo Red | C32H22N6Na2O6S2 | CAS No. 573-58-0
Description: Amyloid fibril binding dye; also a VGlut inhibitor
Chemical Name: 3,3'-[(1,1'-Biphenyl)-4,4'-diyl-bis(2,1-diazenediyl)]bis(4-amino-1-naphthalenesulfonic acid) disodium salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Congo Red

Congo Red is a VGlut inhibitor; decreases synaptic transmission in the dentate gyrus. Also an amyloid fibril-binding dye; inhibits Fib-beta A neurotoxicity by inhibiting fibril formation or by binding to preformed fibrils. Also inhibits the pancreatic islet cell toxicity of diabetes-associated amylin. Excitation wavelength is 497 nm.

Technical Data for Congo Red

M. Wt 696.66
Formula C32H22N6Na2O6S2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 573-58-0
PubChem ID 11313
Smiles NC2=C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C(C=CC=C6)=C6C(S(=O)(O[Na])=O)=C5)C=C4)C=C3)C=C(S(=O)(O[Na])=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Congo Red

Solvent Max Conc. mg/mL Max Conc. mM
water 6.97 10
DMSO 6.97 10

Preparing Stock Solutions for Congo Red

The following data is based on the product molecular weight 696.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.35 mL 71.77 mL 143.54 mL
0.5 mM 2.87 mL 14.35 mL 28.71 mL
1 mM 1.44 mL 7.18 mL 14.35 mL
5 mM 0.29 mL 1.44 mL 2.87 mL

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References for Congo Red

References are publications that support the biological activity of the product.

Lorenzo et al (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc.Natl.Acad.Sci.USA 91 12243 PMID: 7991613

Neale et al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. 38 1060 PMID: 23303071

Neale et al (2013) Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex. Neurochem.Int. 73 159 PMID: 24121008

If you know of a relevant reference for Congo Red, please let us know.

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