Clemastine fumarate

Pricing Availability   Qty
Description: H1 antagonist
Chemical Name: (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for Clemastine fumarate

Clemastine fumarate is a h1-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine.

Compound Libraries for Clemastine fumarate

Clemastine fumarate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Clemastine fumarate

M. Wt 459.97
Formula C21H26ClNO.C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 14976-57-9
PubChem ID 5281069
Smiles [H]OC(=O)\C=C\C(=O)O[H].CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Clemastine fumarate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.2 20

Preparing Stock Solutions for Clemastine fumarate

The following data is based on the product molecular weight 459.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.87 mL 54.35 mL 108.7 mL
1 mM 2.17 mL 10.87 mL 21.74 mL
2 mM 1.09 mL 5.44 mL 10.87 mL
10 mM 0.22 mL 1.09 mL 2.17 mL

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Product Datasheets for Clemastine fumarate

Certificate of Analysis / Product Datasheet
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References for Clemastine fumarate

References are publications that support the biological activity of the product.

Dorsch et al (1982) Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro. Agents Actions 12 113 PMID: 6177209

Hartmann et al (1981) Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 36 737 PMID: 7330790

Nair and Schwartz (1983) Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell.Immunol. 81 45 PMID: 6225527

If you know of a relevant reference for Clemastine fumarate, please let us know.

View Related Products by Product Action

View all Histamine H1 Receptor Antagonists

Keywords: Clemastine fumarate, Clemastine fumarate supplier, H1, antagonist, Receptors, Histamine, antihistamine, histaminergic, promotes, oligodendrocyte, differentiation, remyelination, Other, Differentiation, Products, 1453, Tocris Bioscience

2 Citations for Clemastine fumarate

Citations are publications that use Tocris products. Selected citations for Clemastine fumarate include:

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882

Nörenberg et al (2011) Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem 286 11067 PMID: 21262970

Do you know of a great paper that uses Clemastine fumarate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.