Clemastine fumarate

Pricing Availability Delivery Time Qty
Cat.No. 1453 - Clemastine fumarate | C21H26ClNO.C4H4O4 | CAS No. 14976-57-9
Description: H1 antagonist
Chemical Name: (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

H1-receptor antagonist. Clinically-used antihistamine.

Compound Libraries

Clemastine fumarate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 459.97
Formula C21H26ClNO.C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 14976-57-9
PubChem ID 5281069
InChI Key PMGQWSIVQFOFOQ-YKVZVUFRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23 50
ethanol 4.6 10

Preparing Stock Solutions

The following data is based on the product molecular weight 459.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.87 mL 21.74 mL
5 mM 0.43 mL 2.17 mL 4.35 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dorsch et al (1982) Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro. Agents Actions 12 113 PMID: 6177209

Hartmann et al (1981) Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 36 737 PMID: 7330790

Nair and Schwartz (1983) Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell.Immunol. 81 45 PMID: 6225527


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Keywords: Clemastine fumarate, supplier, H1, antagonist, Receptors, Histamine, antihistamine, histaminergic, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

1 Citation for Clemastine fumarate

Citations are publications that use Tocris products. Selected citations for Clemastine fumarate include:

Nörenberg et al (2011) Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem 286 11067 PMID: 21262970


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