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H1-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 459.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.35 mL||21.74 mL||43.48 mL|
|2.5 mM||0.87 mL||4.35 mL||8.7 mL|
|5 mM||0.43 mL||2.17 mL||4.35 mL|
|25 mM||0.09 mL||0.43 mL||0.87 mL|
References are publications that support the biological activity of the product.
Dorsch et al (1982) Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro. Agents Actions 12 113 PMID: 6177209
Hartmann et al (1981) Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 36 737 PMID: 7330790
Nair and Schwartz (1983) Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell.Immunol. 81 45 PMID: 6225527
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Keywords: Clemastine fumarate, Clemastine fumarate supplier, H1, antagonist, Receptors, Histamine, antihistamine, histaminergic, promotes, oligodendrocyte, differentiation, remyelination, Other, Differentiation, Products, 1453, Tocris Bioscience
2 Citations for Clemastine fumarate
Citations are publications that use Tocris products. Selected citations for Clemastine fumarate include:
Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882
Nörenberg et al (2011) Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem 286 11067 PMID: 21262970
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