Cinanserin hydrochloride

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Cat.No. 0460 - Cinanserin hydrochloride | C20H24N2OS.HCl | CAS No. 54-84-2
Description: Selective 5-HT2 antagonist; also 3C-like proteinase inhibitor
Chemical Name: N-[2-[[3-(Dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (2)

Biological Activity

5-HT2 antagonist. Also inhibits 3C-like proteinase. Inhibits replication of SARS-CoV.

Technical Data

M. Wt 376.94
Formula C20H24N2OS.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 54-84-2
PubChem ID 6433141
InChI Key LXGJPDKYMJJWRB-IERUDJENSA-N
Smiles O=C(/C=C/C2=CC=CC=C2)NC1=CC=CC=C1SCCCN(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50

Preparing Stock Solutions

The following data is based on the product molecular weight 376.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.31 mL 26.53 mL 53.06 mL
2.5 mM 1.06 mL 5.31 mL 10.61 mL
5 mM 0.53 mL 2.65 mL 5.31 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Leysen et al (1981) Receptor binding profile of R-41-468, a novel antagonist at 5HT2 receptors. Life Sci. 28 1015 PMID: 6261070

Pierce et al (1992) Molecular structure basis of ligand selectivity for 5-HT2 versus 5-HT1C cortical receptors. Naunyn Schmiedebergs Arch.Pharmacol. 346 4 PMID: 1407003

Chen et al (2005) Cinanserin is an inhibitor of the 3C-like proteinase of the severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J.Virol. 79 7095 PMID: 15890949


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3 Citations for Cinanserin hydrochloride

Citations are publications that use Tocris products. Selected citations for Cinanserin hydrochloride include:

Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129

Seeburg et al (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci 24 10950 PMID: 15574745


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Literature in this Area

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.