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5-HT2 antagonist. Also inhibits 3C-like proteinase. Inhibits replication of SARS-CoV.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 376.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.31 mL||26.53 mL||53.06 mL|
|2.5 mM||1.06 mL||5.31 mL||10.61 mL|
|5 mM||0.53 mL||2.65 mL||5.31 mL|
|25 mM||0.11 mL||0.53 mL||1.06 mL|
References are publications that support the biological activity of the product.
Leysen et al (1981) Receptor binding profile of R-41-468, a novel antagonist at 5HT2 receptors. Life Sci. 28 1015 PMID: 6261070
Pierce et al (1992) Molecular structure basis of ligand selectivity for 5-HT2 versus 5-HT1C cortical receptors. Naunyn Schmiedebergs Arch.Pharmacol. 346 4 PMID: 1407003
Chen et al (2005) Cinanserin is an inhibitor of the 3C-like proteinase of the severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J.Virol. 79 7095 PMID: 15890949
If you know of a relevant reference for Cinanserin hydrochloride, please let us know.
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3 Citations for Cinanserin hydrochloride
Citations are publications that use Tocris products. Selected citations for Cinanserin hydrochloride include:
Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
Seeburg et al (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci 24 10950 PMID: 15574745
Do you know of a great paper that uses Cinanserin hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.