Cinanserin hydrochloride

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Selective 5-HT2 antagonist; also 3C-like proteinase inhibitor
Chemical Name: N-[2-[[3-(Dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for Cinanserin hydrochloride

Cinanserin hydrochloride is a 5-HT2 antagonist. Also inhibits 3C-like proteinase (3CLpro; Mpro). Inhibits replication of SARS-CoV.

Technical Data for Cinanserin hydrochloride

M. Wt 376.94
Formula C20H24N2OS.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 54-84-2
PubChem ID 6433141
Smiles O=C(/C=C/C2=CC=CC=C2)NC1=CC=CC=C1SCCCN(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cinanserin hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 50

Preparing Stock Solutions for Cinanserin hydrochloride

The following data is based on the product molecular weight 376.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.31 mL 26.53 mL 53.06 mL
2.5 mM 1.06 mL 5.31 mL 10.61 mL
5 mM 0.53 mL 2.65 mL 5.31 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Cinanserin hydrochloride

References for Cinanserin hydrochloride

References are publications that support the biological activity of the product.

Leysen et al (1981) Receptor binding profile of R-41-468, a novel antagonist at 5HT2 receptors. Life Sci. 28 1015 PMID: 6261070

Pierce et al (1992) Molecular structure basis of ligand selectivity for 5-HT2 versus 5-HT1C cortical receptors. Naunyn Schmiedebergs Arch.Pharmacol. 346 4 PMID: 1407003

Chen et al (2005) Cinanserin is an inhibitor of the 3C-like proteinase of the severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J.Virol. 79 7095 PMID: 15890949

If you know of a relevant reference for Cinanserin hydrochloride, please let us know.

View Related Products by Product Action

View all Non-selective 5-HT2 Antagonists

Keywords: Cinanserin hydrochloride, Cinanserin hydrochloride supplier, Selective, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, 3C-like, proteinase, inhibitors, inhibits, SARS-CoV, coronavirus, severe, acute, respiratory, syndrome, Mpro, Non-selective, Other, Proteases, 3C, and, 3CL, Coronavirus, 0460, Tocris Bioscience

3 Citations for Cinanserin hydrochloride

Citations are publications that use Tocris products. Selected citations for Cinanserin hydrochloride include:

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129

Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326

Seeburg et al (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci 24 10950 PMID: 15574745

Do you know of a great paper that uses Cinanserin hydrochloride from Tocris? Please let us know.

Reviews for Cinanserin hydrochloride

There are currently no reviews for this product. Be the first to review Cinanserin hydrochloride and earn rewards!

Have you used Cinanserin hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.