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Selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.74 mL||53.69 mL||107.38 mL|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|2 mM||1.07 mL||5.37 mL||10.74 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
References are publications that support the biological activity of the product.
Peddibhotla et al (2010) Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 53 4793 PMID: 20481485
Shi et al (2010) Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio. 5 287
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Keywords: CID 2858522, CID 2858522 supplier, CID2858522, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, PKC, protein, kinase, C-induced, activation, NF-kB/IkB, 4246, Tocris Bioscience
1 Citation for CID 2858522
Citations are publications that use Tocris products. Selected citations for CID 2858522 include:
Stec et al (2016) Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes. Oncotarget 7 31907 PMID: 27004406
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