CI 994

Pricing Availability Delivery Time Qty
Cat.No. 2952 - CI 994 | C15H15N3O2 | CAS No. 112522-64-2
Description: Class I histone deacetylase inhibitor; orally active
Alternative Names: N-acetyldinaline
Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction.

Compound Libraries

CI 994 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 269.3
Formula C15H15N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 112522-64-2
PubChem ID 2746
InChI Key VAZAPHZUAVEOMC-UHFFFAOYSA-N
Smiles O=C(NC2=C(N)C=CC=C2)C1=CC=C(NC(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.57 mL 37.13 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Beckers et al (2007) Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 121 1138 PMID: 17455259

Gräff et al (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156 261 PMID: 24439381

Kraker et al (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2 401 PMID: 12700284


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Keywords: CI 994, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, CI994, epigenetics, N-acetyldinaline, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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