Orally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 269.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.71 mL||18.57 mL||37.13 mL|
|5 mM||0.74 mL||3.71 mL||7.43 mL|
|10 mM||0.37 mL||1.86 mL||3.71 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the products' biological activity.
Beckers et al (2007) Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 121 1138 PMID: 17455259
Gräff et al (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156 261 PMID: 24439381
Kraker et al (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2 401 PMID: 12700284
If you know of a relevant reference for CI 994, please let us know.
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Keywords: CI 994, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, CI994, epigenetics, N-acetyldinaline, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
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