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Cat.No. 0456 - Chlormezanone | C11H12ClNO3S | CAS No. 80-77-3
Description: Skeletal muscle relaxant
Chemical Name: 2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one-1,1-dioxide
Purity: ≥99% (HPLC)

Biological Activity

Anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABAA receptors.

Technical Data

M. Wt 273.73
Formula C11H12ClNO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 80-77-3
PubChem ID 2717
Smiles CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.37 100
ethanol 6.84 25

Preparing Stock Solutions

The following data is based on the product molecular weight 273.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.27 mL 36.53 mL
5 mM 0.73 mL 3.65 mL 7.31 mL
10 mM 0.37 mL 1.83 mL 3.65 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Ervin and Cooper (1988) Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 245 137 PMID: 2896235

Simiand et al (1989) Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 297 272 PMID: 2567153

Merck Index 12 2155 PMID:

If you know of a relevant reference for Chlormezanone, please let us know.

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Keywords: Chlormezanone, supplier, Skeletal, muscle, relaxant, GABAA, Receptors, benzodiazepine, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

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