Pricing Availability   Qty
Description: Positive allosteric modulator of benzodiazepine site
Chemical Name: 2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one-1,1-dioxide
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Chlormezanone

Chlormezanone is a anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABAA receptors.

Compound Libraries for Chlormezanone

Chlormezanone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Chlormezanone

M. Wt 273.73
Formula C11H12ClNO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 80-77-3
PubChem ID 2717
Smiles CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Chlormezanone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.37 100
ethanol 6.84 25

Preparing Stock Solutions for Chlormezanone

The following data is based on the product molecular weight 273.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.27 mL 36.53 mL
5 mM 0.73 mL 3.65 mL 7.31 mL
10 mM 0.37 mL 1.83 mL 3.65 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets for Chlormezanone

Certificate of Analysis / Product Datasheet
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References for Chlormezanone

References are publications that support the biological activity of the product.

Ervin and Cooper (1988) Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 245 137 PMID: 2896235

Simiand et al (1989) Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 297 272 PMID: 2567153

Merck Index 12 2155

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Keywords: Chlormezanone, Chlormezanone supplier, Skeletal, muscle, relaxant, GABAA, Receptors, benzodiazepine, PAM, 0456, Tocris Bioscience

Citations for Chlormezanone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.