CGS 20625

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Cat.No. 2467 - CGS 20625 | C18H19N3O2 | CAS No. 111205-55-1
Description: Selective central benzodiazepine receptor partial agonist
Chemical Name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
Purity: ≥99% (HPLC)

Biological Activity

Selective, partial agonist for the benzodiazepine binding site of the GABAA receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Displays anxiolytic activity in vivo following oral administration. .

Compound Libraries

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Technical Data

M. Wt 309.36
Formula C18H19N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 111205-55-1
PubChem ID 163844
Smiles COC1=CC=C(C=C1)N1N=C2C(=CNC3=C2CCCCC3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.94 100
ethanol 7.73 25

Preparing Stock Solutions

The following data is based on the product molecular weight 309.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.16 mL 32.32 mL
5 mM 0.65 mL 3.23 mL 6.46 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Bennett (1987) Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions. Physiol.Behav. 41 241 PMID: 2893398

Williams et al (1989) CGS 20625, a novel pyrazolopyridine anxiolytic. J.Pharmacol.Exp.Ther. 248 89 PMID: 2563294

Jarvis et al (1990) CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity. Prog.Clin.Biol.Res. 361 477 PMID: 1981266

If you know of a relevant reference for CGS 20625, please let us know.

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Keywords: CGS 20625, supplier, Selective, central, benzodiazepine, receptor, partial, agonists, GABAA, Receptors, CGS20625, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

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