Pricing Availability   Qty
Description: Noncompetitive Epac1 inhibitor
Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for CE3F4

CE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.

Compound Libraries for CE3F4

CE3F4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CE3F4

M. Wt 351.01
Formula C11H10Br2FNO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 143703-25-7
PubChem ID 21781066
Smiles BrC1=C(F)C(Br)=C(CCC(C)N2C=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CE3F4

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.1 100
ethanol 17.55 50

Preparing Stock Solutions for CE3F4

The following data is based on the product molecular weight 351.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.24 mL 28.49 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References for CE3F4

References are publications that support the biological activity of the product.

Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55 PMID: 25411381

Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192 PMID: 23139415

Chen et al (2022) The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Transl.Med. 10 1377

If you know of a relevant reference for CE3F4, please let us know.

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Keywords: CE3F4, CE3F4 supplier, noncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, Rap, guanine, nucleotide, exchange, factor, 3, RAPGEF3, cAMP, GEFI, EPAC, 4793, Tocris Bioscience

4 Citations for CE3F4

Citations are publications that use Tocris products. Selected citations for CE3F4 include:

Chen et al (2022) The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Trans.Med. 10 1377

Paul A et al (2020) Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife 9 PMID: 32014112

Jakobsen et al (2019) Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function. J Neurosci Res 97 1018 PMID: 31172581

Derek C et al (2021) Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci 41 2883-2898 PMID: 33593853

Do you know of a great paper that uses CE3F4 from Tocris? Please let us know.

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