CE3F4

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Cat.No. 4793 - CE3F4 | C11H10Br2FNO | CAS No. 143703-25-7
Description: Uncompetitive Epac1 inhibitor
Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Uncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.

Compound Libraries

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Technical Data

M. Wt 351.01
Formula C11H10Br2FNO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 143703-25-7
PubChem ID 21781066
InChI Key ZZLQPWXVZCPUGC-UHFFFAOYSA-N
Smiles BrC1=C(F)C(Br)=C(CCC(C)N2C=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.1 100
ethanol 17.55 50

Preparing Stock Solutions

The following data is based on the product molecular weight 351.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.24 mL 28.49 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55 PMID: 25411381

Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192 PMID: 23139415


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Keywords: CE3F4, supplier, uncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, GTPase, Tocris Bioscience

Citations for CE3F4

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New Product Guide (Spring/Summer 2017)

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  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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