Isoproterenol hydrochloride

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Cat.No. 1747 - Isoproterenol hydrochloride | C11H17NO3.HCl | CAS No. 51-30-9
Description: Standard selective β agonist
Alternative Names: Isoprenaline
Chemical Name: 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (14)

Biological Activity

Standard selective β-adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo. Also available as part of the β-Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™.

Technical Data

M. Wt 247.72
Formula C11H17NO3.HCl
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 51-30-9
PubChem ID 5807
InChI Key IROWCYIEJAOFOW-UHFFFAOYSA-N
Smiles Cl.CC(C)NCC(O)C1=CC(O)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.77 100
phosphate buffered saline 12.39 50

Preparing Stock Solutions

The following data is based on the product molecular weight 247.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.04 mL 20.18 mL 40.37 mL
5 mM 0.81 mL 4.04 mL 8.07 mL
10 mM 0.4 mL 2.02 mL 4.04 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Akimoto et al (2002) Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline. J.Smooth Muscle Res. 38 87 PMID: 12596888

Lotti et al (1982) Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment. J.Auton.Pharmacol. 2 169 PMID: 6292228

Schmitt and Stork (2000) β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf. J.Biol.Chem. 275 25342 PMID: 10840035


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Keywords: selective β-adrenoceptor beta-adrenoceptor b-adrenoceptor β-adrenergic beta-adrenergic b-adrenergic agonists Receptors Non-Selective Isoprenaline Non-selective Adrenergic Beta Receptors

14 Citations for Isoproterenol hydrochloride

Citations are publications that use Tocris products. Selected citations for Isoproterenol hydrochloride include:

Santulli et al (2012) Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor. J Cell Biol 61 692 PMID: 22315324

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474 PMID: 22164209

Duncan et al (2010) The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biol Chem 31 1646 PMID: 20525077

Maehashi et al (2008) Bitter peptides activate hTAS2Rs, the human bitter receptors. PLoS One 365 851 PMID: 18037373

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Sci Rep 24 7745 PMID: 15342742

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448

Sun et al (2015) Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. Nat Commun 5 15950 PMID: 26516061

Siuda et al (2015) Optodynamic simulation of β-adrenergic receptor signalling. Circ Arrhythm Electrophysiol 6 8480 PMID: 26412387

Lang et al (2015) Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart. Cereb Cortex 8 409 PMID: 25673629

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. J Mol Cell Cardiol 10 e0132884 PMID: 26222156

Hansen and Manahan-Vaughan (2015) Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors. Eur J Neurosci 25 1889 PMID: 24464942

Gray et al (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. Biochem Biophys Res Commun 289 14600 PMID: 24706758

Yang et al (2014) PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. Diabetes 66 83 PMID: 24225179


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