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CDDO-Me is a Nrf2 pathway activator. Induces expression of Nrf-2 regulated, cytoprotective genes in vivo. Also blocks the NF-κB pathway by direct inhibition of IKKβ. Inhibits production of a wide range of inflammatory mediators in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 505.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.95 mL||19.77 mL||39.55 mL|
|2.5 mM||0.79 mL||3.95 mL||7.91 mL|
|5 mM||0.4 mL||1.98 mL||3.95 mL|
|25 mM||0.08 mL||0.4 mL||0.79 mL|
References are publications that support the biological activity of the product.
Ahmad et al (2006) Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179. J.Biol.Chem. 281 35764 PMID: 16998237
Yates et al (2007) Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol.Cancer Ther. 6 154 PMID: 17237276
Liby & Sporn (2012) Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacol.Rev. 64 972 PMID: 22966038
If you know of a relevant reference for CDDO-Me, please let us know.
Keywords: CDDO-Me, CDDO-Me supplier, CDDO, methyl, ester, bardoxolone, Nrf2, activators, activates, NF-kappaB, inhibitors, inhibits, IKKbeta, IkappaB, NF-kB/IkB, IkB, Kinase, 6646, Tocris Bioscience
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