Cardionogen 1

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Cat.No. 4475 - Cardionogen 1 | C13H14N4OS | CAS No. 577696-37-8
Description: Inhibitor of Wnt/β-catenin signaling
Chemical Name: 6-Cyclohexyl-3-(2-furanyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
Purity: ≥99% (HPLC)
Literature (1)
Pathways (1)

Biological Activity

Wnt signaling modulator. Potently inhibits Wnt/β-catenin-dependent transcription in murine ES cells (EC50 = 23 nM) and zebrafish embryos. Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation.

Technical Data

M. Wt 274.34
Formula C13H14N4OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 577696-37-8
PubChem ID 663145
Smiles C12=NN=C(C3=CC=CO3)N1N=C(C4CCCCC4)S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.49 20
ethanol 2.74 10

Preparing Stock Solutions

The following data is based on the product molecular weight 274.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 18.23 mL 91.13 mL 182.26 mL
1 mM 3.65 mL 18.23 mL 36.45 mL
2 mM 1.82 mL 9.11 mL 18.23 mL
10 mM 0.36 mL 1.82 mL 3.65 mL

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References are publications that support the biological activity of the product.

Ni et al (2011) Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem.Biol. 18 1658 PMID: 22195568

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Keywords: Cardionogen 1, Cardionogen 1 supplier, Cardionogen1, Wnt/B-catenin, beta-catenin, β-catenin, embryonic, stem, cells, inhibitors, inhibits, cardiac, hyperplasia, differentiation, Beta-catenin, ESCs, and, iPSC, Cardiomyocyte, Stem, Cells, 4475, Tocris Bioscience

Citations for Cardionogen 1

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Cardionogen 1


Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.