Camostat mesylate

Pricing Availability   Qty
Description: Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells
Chemical Name: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate
Purity: ≥98% (HPLC)
Citations (7)
Reviews (1)

Biological Activity for Camostat mesylate

Camostat mesylate is an orally active protease inhibitor. Inhibits trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration. Also inhibits transmembrane serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (COVID-19) into lung cells in vitro.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Camostat mesylate

Camostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Camostat mesylate

M. Wt 494.52
Formula C20H22N4O5.CH3SO3H
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 59721-29-8
PubChem ID 43071
Smiles O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Camostat mesylate

Solvent Max Conc. mg/mL Max Conc. mM
water 24.73 50
DMSO 49.45 100

Preparing Stock Solutions for Camostat mesylate

The following data is based on the product molecular weight 494.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.22 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for Camostat mesylate

Certificate of Analysis / Product Datasheet
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References for Camostat mesylate

References are publications that support the biological activity of the product.

Horiuchi et al (1990) Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 252 320 PMID: 1688943

Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 80 1999 PMID: 17433371

Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 181 271 PMID: 32142651

If you know of a relevant reference for Camostat mesylate, please let us know.

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Keywords: Camostat mesylate, Camostat mesylate supplier, Orally, active, proteases, inhibitors, inhibits, Proteinases, trypsin, plasmin, kallikrein, thrombin, serine, protease, TMPRSS2, SARS-Cov-2, COVID-19, coronaviruses, severe, acute, respiratory, syndrome, Other, Proteases, Coronavirus, 3193, Tocris Bioscience

7 Citations for Camostat mesylate

Citations are publications that use Tocris products. Selected citations for Camostat mesylate include:

Strobelt et al (2022) Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism. Sci.Rep. 12 5758 PMID: 35388061

Shirato et al (2017) Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. J Virol 91 PMID: 27733646

Gamble et al (2013) Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. Leukemia 185 41518 PMID: 23816469

Bertram et al (2013) TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. J Virol 87 6150 PMID: 23536651

Do you know of a great paper that uses Camostat mesylate from Tocris? Please let us know.

Reviews for Camostat mesylate

Average Rating: 3 (Based on 1 Review.)

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Used in cell culture.
By Irving Garcia on 11/19/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: ES cells

Used in cell culture to compare with nanocamostat. Need to run qPCR for final outcome.