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Description: Two-photon polarity-sensitive lipid membrane probe
Chemical Name: N-Methyl-N-[6-(1-oxododecyl)-2-naphthalenyl]glycine
Purity: ≥95% (HPLC)
Citations (1)
Literature (1)

Biological Activity for C-Laurdan

C-Laurdan is a fluorescent probe for imaging lipid rafts. Used to detect membrane polarity via one and two-photon fluorecence imaging. Two photon excitation spectra = 780 nm; one photon absorption/emission spectra = 348/423 nm; Quantum yield = 0.43.

Optical Data for C-Laurdan

C-Laurdan Dye Spectra
Emission Color Blue
λabs 348 nm
λem 423 nm
Quantum Yield (φ) 0.43
Application One and Two-photon Microscopy for Membrane Polarity

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Technical Data for C-Laurdan

M. Wt 397.56
Formula C25H35NO3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 959839-06-6
PubChem ID 24966947

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C-Laurdan

Solvent Max Conc. mg/mL Max Conc. mM
DMF 39.76 100
ethanol 3.98 10
DMSO 7.95 20

Preparing Stock Solutions for C-Laurdan

The following data is based on the product molecular weight 397.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.15 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for C-Laurdan

References are publications that support the biological activity of the product.

Kim et al (2007) A two-photon fluorescent probe for lipid raft imaging: C-laurdan. Chembiochem 8 553 PMID: 17300111

Barucha-Kraszewska et al (2013) Will C-Laurdan dethrone Laurdan in fluorescent solvent relaxation techniques for lipid membrane studies? Langmuir 29 1174 PMID: 23311388

Mazeres et al (2014) Characterization of M-laurdan, a versatile probe to explore order in lipid membranes. F1000Res. 3 172 PMID: 25485094

If you know of a relevant reference for C-Laurdan, please let us know.

Keywords: C-Laurdan, C-Laurdan supplier, fluorescent, probe, imaging, lipid, rafts, membrane, polarity, two-photon, 2-photon, one-photon, 1-photon, Fluorescent, Lipid, Probes, and, Cell, Membrane, Stains, 7273, Tocris Bioscience

1 Citation for C-Laurdan

Citations are publications that use Tocris products. Selected citations for C-Laurdan include:

Muriel et al (2021) Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast. EMBO J 40 e107966 PMID: 34520050

Do you know of a great paper that uses C-Laurdan from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

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