Butabindide oxalate

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Cat.No. 1323 - Butabindide oxalate | C17H25N3O2.C2H2O4 | CAS No. 185213-03-0
Description: High affinity CCK-inactivating serine protease inhibitor
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity

High affinity, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Licensing Information

Sold with the permission of INSERM and UCL

Technical Data

M. Wt 393.44
Formula C17H25N3O2.C2H2O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 185213-03-0
PubChem ID 56972132
Smiles O=C(O)C(O)=O.O=[C@]([C@@H](N)CC)N([C@H]([C@@](NCCCC)=O)C2)C1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 39.34 100
DMSO 39.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664 PMID: 10691692

Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173 PMID: 9668104

Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403 PMID: 8602240

If you know of a relevant reference for Butabindide oxalate, please let us know.

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Keywords: Butabindide oxalate, Butabindide oxalate supplier, CCK-inactivating, serine, protease, inhibitors, inhibits, tripeptidyl, peptidase, II, Proteases, Proteinases, Cholecystokinin, Other, Non-selective, CCK, 1323, Tocris Bioscience

3 Citations for Butabindide oxalate

Citations are publications that use Tocris products. Selected citations for Butabindide oxalate include:

Duensing et al (2010) Tripeptidyl Peptidase II Is Required for c-MYC-Induced Centriole Overduplication and a Novel Therapeutic Target in c-MYC-Associated Neoplasms. Genes Cancer 1 883 PMID: 21647238

Lorente et al (2011) Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem 286 38054 PMID: 21914809

Dasgupta et al (2014) Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells. PLoS One 9 e103604 PMID: 25079948

Do you know of a great paper that uses Butabindide oxalate from Tocris? Please let us know.

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Literature in this Area

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