Butabindide oxalate

Pricing Availability   Qty
Cat.No. 1323 - Butabindide oxalate | C17H25N3O2.C2H2O4 | CAS No. 185213-03-0
Description: CCK-inactivating serine protease inhibitor
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Licensing Information

Sold with the permission of INSERM and UCL

Technical Data

M. Wt 393.44
Formula C17H25N3O2.C2H2O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 185213-03-0
PubChem ID 56972132
InChI Key KKMJFDVOXSGHBF-SLHAJLBXSA-N
Smiles O=C(O)C(O)=O.O=[C@]([C@@H](N)CC)N([C@H]([C@@](NCCCC)=O)C2)C1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.34 100
DMSO 39.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664 PMID: 10691692

Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173 PMID: 9668104

Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403 PMID: 8602240


If you know of a relevant reference for Butabindide oxalate, please let us know.

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: Butabindide oxalate, Butabindide oxalate supplier, CCK-inactivating, serine, protease, inhibitors, inhibits, tripeptidyl, peptidase, II, Proteases, Proteinases, Cholecystokinin, Other, Non-selective, CCK, 1323, Tocris Bioscience

3 Citations for Butabindide oxalate

Citations are publications that use Tocris products. Selected citations for Butabindide oxalate include:

Lorente et al (2011) Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem 286 38054 PMID: 21914809

Dasgupta et al (2014) Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells. PLoS One 9 e103604 PMID: 25079948

Duensing et al (2010) Tripeptidyl Peptidase II Is Required for c-MYC-Induced Centriole Overduplication and a Novel Therapeutic Target in c-MYC-Associated Neoplasms. Genes Cancer 1 883 PMID: 21647238


Do you know of a great paper that uses Butabindide oxalate from Tocris? Please let us know.

Reviews for Butabindide oxalate

There are currently no reviews for this product. Be the first to review Butabindide oxalate and earn rewards!

Have you used Butabindide oxalate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells