Butabindide oxalate

Pricing Availability Delivery Time Qty
Cat.No. 1323 - Butabindide oxalate | C17H25N3O2.C2H2O4 | CAS No. 185213-03-0
Description: CCK-inactivating serine protease inhibitor
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Licensing Information

Sold with the permission of INSERM and UCL

Technical Data

M. Wt 393.44
Formula C17H25N3O2.C2H2O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 185213-03-0
PubChem ID 56972132
InChI Key KKMJFDVOXSGHBF-SLHAJLBXSA-N
Smiles O=C(O)C(O)=O.O=[C@]([C@@H](N)CC)N([C@H]([C@@](NCCCC)=O)C2)C1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.34 100
water 39.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664 PMID: 10691692

Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173 PMID: 9668104

Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403 PMID: 8602240


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Keywords: Butabindide oxalate, supplier, CCK-inactivating, serine, protease, inhibitors, inhibits, tripeptidyl, peptidase, II, Proteases, Proteinases, Cholecystokinin, Other, Proteases, Non-selective, CCK, Other, Proteases, Tocris Bioscience

1 Citation for Butabindide oxalate

Citations are publications that use Tocris products. Selected citations for Butabindide oxalate include:

Lorente et al (2011) Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem 286 38054 PMID: 21914809


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Literature in this Area

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