BIO-acetoxime

Pricing Availability   Qty
Description: Selective GSK-3α/β inhibitor
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (5)
Pathways (1)

Biological Activity for BIO-acetoxime

BIO-acetoxime is a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Data for BIO-acetoxime

M. Wt 398.21
Formula C18H12BrN3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 667463-85-6
PubChem ID 24906283
InChI Key ORWSYHWTBSHFIV-UHFFFAOYSA-N
Smiles O=C(NC4=C3C=CC(Br)=C4)/C3=C2NC1=CC=CC=C1/C/2=N\OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BIO-acetoxime

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.96 20

Preparing Stock Solutions for BIO-acetoxime

The following data is based on the product molecular weight 398.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.56 mL 62.78 mL 125.56 mL
1 mM 2.51 mL 12.56 mL 25.11 mL
2 mM 1.26 mL 6.28 mL 12.56 mL
10 mM 0.25 mL 1.26 mL 2.51 mL

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Product Datasheets for BIO-acetoxime

Certificate of Analysis / Product Datasheet
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References for BIO-acetoxime

References are publications that support the biological activity of the product.

Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195

Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962


If you know of a relevant reference for BIO-acetoxime, please let us know.

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Keywords: BIO-acetoxime, BIO-acetoxime supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, inhibits, selective, Glycogen, Synthase, Kinase, Stem, Cell, Signaling, 3874, Tocris Bioscience

4 Citations for BIO-acetoxime

Citations are publications that use Tocris products. Selected citations for BIO-acetoxime include:

Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417 PMID: 25616418

Shi et al (2017) Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell 20 675 PMID: 28196600

Julian et al (2019) FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep 28 382-393.e7 PMID: 31291575

Matthew W et al (2019) GSK3 regulates hair cell fate in the developing mammalian cochlea. Dev Biol 453 191-205 PMID: 31185200


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for BIO-acetoxime

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.