BIO-acetoxime

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Cat.No. 3874 - BIO-acetoxime | C18H12BrN3O3 | CAS No. 667463-85-6
Description: Selective GSK-3α/β inhibitor
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Compound Libraries

BIO-acetoxime is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 398.21
Formula C18H12BrN3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 667463-85-6
PubChem ID 24906283
InChI Key ORWSYHWTBSHFIV-UHFFFAOYSA-N
Smiles O=C(NC4=C3C=CC(Br)=C4)/C3=C2NC1=CC=CC=C1/C/2=N\OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.96 20

Preparing Stock Solutions

The following data is based on the product molecular weight 398.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.56 mL 25.11 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195

Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962


If you know of a relevant reference for BIO-acetoxime, please let us know.

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View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: BIO-acetoxime glycogen synthase kinases 3 GSK-3 GSK3 Gsk3alpha/beta GSK3beta inhibitors inhibits selective Glycogen Synthase Kinase 3

1 Citation for BIO-acetoxime

Citations are publications that use Tocris products. Selected citations for BIO-acetoxime include:

Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417 PMID: 25616418


Do you know of a great paper that uses BIO-acetoxime from Tocris? If so please let us know.

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Pathways for BIO-acetoxime

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