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Biological Activity for BIO-acetoxime
BIO-acetoxime is a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Technical Data for BIO-acetoxime
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIO-acetoxime
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BIO-acetoxime
The following data is based on the product molecular weight 398.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.56 mL||62.78 mL||125.56 mL|
|1 mM||2.51 mL||12.56 mL||25.11 mL|
|2 mM||1.26 mL||6.28 mL||12.56 mL|
|10 mM||0.25 mL||1.26 mL||2.51 mL|
References for BIO-acetoxime
References are publications that support the biological activity of the product.
Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195
Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962
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Keywords: BIO-acetoxime, BIO-acetoxime supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, inhibits, selective, Glycogen, Synthase, Kinase, Stem, Cell, Signaling, 3874, Tocris Bioscience
4 Citations for BIO-acetoxime
Citations are publications that use Tocris products. Selected citations for BIO-acetoxime include:
Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417 PMID: 25616418
Shi et al (2017) Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell 20 675 PMID: 28196600
Julian et al (2019) FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep 28 382-393.e7 PMID: 31291575
Matthew W et al (2019) GSK3 regulates hair cell fate in the developing mammalian cochlea. Dev Biol 453 191-205 PMID: 31185200
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.