Selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 398.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.51 mL||12.56 mL||25.11 mL|
|5 mM||0.5 mL||2.51 mL||5.02 mL|
|10 mM||0.25 mL||1.26 mL||2.51 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the products' biological activity.
Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195
Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962
If you know of a relevant reference for BIO-acetoxime, please let us know.
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Keywords: BIO-acetoxime, supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, inhibits, selective, Glycogen, Synthase, Kinase, 3, Stem, Cell, Signaling, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience
1 Citation for BIO-acetoxime
Citations are publications that use Tocris products. Selected citations for BIO-acetoxime include:
Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417 PMID: 25616418
Do you know of a great paper that uses BIO-acetoxime from Tocris? If so please let us know.
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