BIO-acetoxime

Discontinued Product

BIO-acetoxime (Cat. No. 3874) has been withdrawn from sale for commercial reasons.
Description: Selective GSK-3α/β inhibitor
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (4)
Pathways (1)

Biological Activity for BIO-acetoxime

BIO-acetoxime is a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Data for BIO-acetoxime

M. Wt 398.21
Formula C18H12BrN3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 667463-85-6
PubChem ID 24906283
InChI Key ORWSYHWTBSHFIV-UHFFFAOYSA-N
Smiles O=C(NC4=C3C=CC(Br)=C4)/C3=C2NC1=CC=CC=C1/C/2=N\OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BIO-acetoxime

Certificate of Analysis / Product Datasheet
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References for BIO-acetoxime

References are publications that support the biological activity of the product.

Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195

Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962

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Keywords: BIO-acetoxime, BIO-acetoxime supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, inhibits, selective, Glycogen, Synthase, Kinase, Stem, Cell, Signaling, 3874, Tocris Bioscience

4 Citations for BIO-acetoxime

Citations are publications that use Tocris products. Selected citations for BIO-acetoxime include:

Julian et al (2019) FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep 28 382-393.e7 PMID: 31291575

Matthew W et al (2019) GSK3 regulates hair cell fate in the developing mammalian cochlea. Dev Biol 453 191-205 PMID: 31185200

Shi et al (2017) Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell 20 675 PMID: 28196600

Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417 PMID: 25616418


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for BIO-acetoxime

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.