BDS I

Pricing Availability   Qty
Cat.No. 5184 - BDS I | Ala-Ala-Pro-Cys-Phe-Cys-Ser-Gly-Lys-Pro-Gly-Arg-Gly-Asp-Leu-Trp-Ile-Leu-Arg-Gly-Thr-Cys-Pro-Gly-Gly-Tyr-Gly-Tyr-Thr-Ser-Asn-Cys-Tyr-Lys-Trp-Pro-Asn-Ile-Cys-Cys-Tyr-Pro-His
Description: Potent and reversible Kv3.4 potassium channel blocker; neuroprotective
Alternative Names: Blood depressing substance 1
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.

Technical Data

M. Wt 4708.37
Formula C210H297N57O56S6
Sequence AAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH

(Modifications: Disulfide bridge: 4-39,6-32,22-40)

Storage Store at -20°C
PubChem ID 90489021
InChI Key NHDQBZJQNKDJOQ-UHFFFAOYSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC1=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(O)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N3)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Diochot et al (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J.Biol.Chem. 273 6744 PMID: 9506974

Liu et al (2012) Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. J.Neurophysiol. 107 3155 PMID: 22442564

Pannaccione et al (2007) Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol.Pharmacol. 72 665 PMID: 17495071


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Keywords: BDS I, BDS I supplier, BDSI, blood, depressing, substance, 1, potent, reversible, Kv3.4, potassium, channels, blockers, attenuated, inactivation, sodium, currents, Nav1.7, and, Nav1.3, neuroprotective, venoms, BDS1, BDS, BDS-1, Blood, Voltage-Gated, Potassium, Channels, Voltage-gated, Sodium, 5184, Tocris Bioscience

Citations for BDS I

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Reviews for BDS I

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Great water soluble toxin for Kv blocking.
By Anonymous on 10/22/2018
Assay Type: In Vitro
Species: Human

BDS I toxin is stable, water soluble and thus a suitable choice in Kv3.4 channel activity monitoring.The product worked ideally and gave similar data patterns every single time.

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