Bax inhibitor peptide P5

Discontinued Product

Unfortunately Bax inhibitor peptide P5 (Cat. No. 1786) has been withdrawn from sale for commercial reasons.
Cat.No. 1786 - Bax inhibitor peptide P5 | Pro-Met-Leu-Lys-Glu | CAS No. 579492-83-4
Description: Inhibitor of Bax-mediated apoptosis
Datasheet
Citations
Literature
Pathways

Biological Activity

Originally reported to be a cell-permeable synthetic peptide inhibitor of Bax that blocks apoptosis. Also available: Bax inhibitor peptide V5 (Cat. No. 1785) and Negative control (Cat. No. 1787).

Licensing Information

Sold under license

Technical Data

M. Wt 616.77
Formula C27H48N6O8S
Sequence PMLKE
Storage Desiccate at -20°C
CAS Number 579492-83-4
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 616.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.11 mL 16.21 mL
5 mM 0.32 mL 1.62 mL 3.24 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sawada et al (2003) Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat.Cell.Biol. 5 352 PMID: 12652309

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Keywords: inhibitors inhibits Bax-mediated apoptosis Bcl-XL Mcl-1 Bcl-2 Family Bax inhibitor peptideP5 Bcl-2 Family

Citations for Bax inhibitor peptide P5

Citations are publications that use Tocris products.

Currently there are no citations for Bax inhibitor peptide P5.

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Reviews

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Literature in this Area

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Bax inhibitor peptide P5

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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