Bax inhibitor peptide V5

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Cat.No. 1785 - Bax inhibitor peptide V5 | Val-Pro-Met-Leu-Lys | CAS No. 579492-81-2
Description: Inhibitor of Bax-mediated apoptosis
Datasheet
Citations (2)
Reviews
Literature
Pathways

Biological Activity

Cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. Designed based on the Bax-binding domain of human Ku70. Inhibits Bax-mediated apoptosis in vitro. Shown to inhibit anti-cancer drug-induced apoptosis in vitro.

Control Peptide also available.

Licensing Information

Sold under license

Technical Data

M. Wt 586.79
Formula C27H50N6O6S
Sequence VPMLK
Storage Desiccate at -20°C
CAS Number 579492-81-2
PubChem ID 10129115
InChI Key NHMUTADCTDDWPV-YFNVTMOMSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Sawatzky et al (2006) The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. Am.J.Pathol. 168 33 PMID: 16400007

Yoshida et al (2004) Bax-inhibiting peptide derived from mouse and rat Ku70. Biochem.Biophys.Res.Commun. 321 961 PMID: 15358121


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Keywords: Bax inhibitor peptide V5, Bax inhibitor peptide V5 supplier, inhibitors, inhibits, Bax-mediated, apoptosis, Bcl-XL, Mcl-1, Bcl-2, Family, Bax, inhibitor, peptideV5, 1785, Tocris Bioscience

2 Citations for Bax inhibitor peptide V5

Citations are publications that use Tocris products. Selected citations for Bax inhibitor peptide V5 include:

Lin et al (2014) Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin via enhancing apoptosis pathways in vitro and in vivo. Toxicol Sci 139 108 PMID: 24563380

Lee et al (2010) Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells. J Cell Sci 123 1634 PMID: 20406888


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

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  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Neurodegeneration Product Guide

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Parkinson's

Parkinson's Poster

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Bax inhibitor peptide V5

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.