Bax inhibitor peptide V5

Discontinued Product

Bax inhibitor peptide V5 (Cat. No. 1785) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of Bax-mediated apoptosis
Citations (2)
Literature (2)
Pathways (1)

Biological Activity for Bax inhibitor peptide V5

Bax inhibitor peptide V5 is a cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. Designed based on the Bax-binding domain of human Ku70. Inhibits Bax-mediated apoptosis in vitro. Shown to inhibit anti-cancer drug-induced apoptosis in vitro.

Control Peptide also available.

Licensing Information

Sold under license

Technical Data for Bax inhibitor peptide V5

M. Wt 586.79
Formula C27H50N6O6S
Sequence VPMLK
Storage Desiccate at -20°C
CAS Number 579492-81-2
PubChem ID 10129115
Smiles [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Bax inhibitor peptide V5

Certificate of Analysis / Product Datasheet
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References for Bax inhibitor peptide V5

References are publications that support the biological activity of the product.

Sawatzky et al (2006) The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. Am.J.Pathol. 168 33 PMID: 16400007

Yoshida et al (2004) Bax-inhibiting peptide derived from mouse and rat Ku70. Biochem.Biophys.Res.Commun. 321 961 PMID: 15358121

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Keywords: Bax inhibitor peptide V5, Bax inhibitor peptide V5 supplier, inhibitors, inhibits, Bax-mediated, apoptosis, Bcl-XL, Mcl-1, Bcl-2, Family, Bax, inhibitor, peptideV5, 1785, Tocris Bioscience

2 Citations for Bax inhibitor peptide V5

Citations are publications that use Tocris products. Selected citations for Bax inhibitor peptide V5 include:

Lee et al (2010) Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells. J Cell Sci 123 1634 PMID: 20406888

Lin et al (2014) Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisp. via enhancing apoptosis pathways in vitro and in vivo. Toxicol Sci 139 108 PMID: 24563380

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for Bax inhibitor peptide V5

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.