BAG 956

Pricing Availability   Qty
Description: Dual PI 3-kinase and PDPK1 (PDK1) inhibitor
Chemical Name: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
Purity: ≥98% (HPLC)

Biological Activity for BAG 956

BAG 956 is a dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.

Compound Libraries for BAG 956

BAG 956 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BAG 956

M. Wt 427.5
Formula C28H21N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 853910-02-8
PubChem ID 24882589
Smiles CC3=NC1=C(N3C4=CC=C(C(C)(C#N)C)C=C4)C2=C(C=CC(C#CC5=CN=CC=C5)=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAG 956

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.1 40
ethanol 8.55 20

Preparing Stock Solutions for BAG 956

The following data is based on the product molecular weight 427.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 5.85 mL 29.24 mL 58.48 mL
2 mM 1.17 mL 5.85 mL 11.7 mL
4 mM 0.58 mL 2.92 mL 5.85 mL
20 mM 0.12 mL 0.58 mL 1.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for BAG 956

References are publications that support the biological activity of the product.

Stauffer et al (2008) Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway. Bioorg.Med.Chem.Lett. 18 1027 PMID: 18248814

Weisberg et al (2008) Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood 111 3723 PMID: 18184863

Marone et al (2009) Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors. Mol.Cancer Res. 7 601 PMID: 19372588

If you know of a relevant reference for BAG 956, please let us know.

View Related Products by Product Action

View all PI 3-kinase Inhibitors

Keywords: BAG 956, BAG 956 supplier, Dual, inhibitors, PDK, PDK1, PI3K, p110, inhibits, PI, 3-kinases, Signaling, Signalling, Phosphoinositide, Kinases, PIP2, Inositol, Lipids, cAMP, 3-phosphoinositide, dependent, protein, kinase-1, BAG956, PDPK1, 3-Kinase, Phosphoinositide-dependent, Kinase, 1, 3606, Tocris Bioscience

Citations for BAG 956

Citations are publications that use Tocris products.

Currently there are no citations for BAG 956. Do you know of a great paper that uses BAG 956 from Tocris? Please let us know.

Reviews for BAG 956

There are currently no reviews for this product. Be the first to review BAG 956 and earn rewards!

Have you used BAG 956?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review