AZD 3147

Pricing Availability   Qty
Cat.No. 5615 - AZD 3147 | C24H31N5O4S2 | CAS No. 1101810-02-9
Description: Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
Chemical Name: N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea
Purity: ≥95% (HPLC)
Literature (3)
Pathways (1)

Biological Activity for AZD 3147

AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

Compound Libraries for AZD 3147

AZD 3147 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 3147

M. Wt 517.66
Formula C24H31N5O4S2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1101810-02-9
PubChem ID 25168990
Smiles OCCNC(NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5[C@@H](C)COCC5)=N2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 3147

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.77 100
1eq. HCl 51.77 100

Preparing Stock Solutions for AZD 3147

The following data is based on the product molecular weight 517.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for AZD 3147

References are publications that support the biological activity of the product.

Pike et al (2015) Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 58 2326 PMID: 25643210

If you know of a relevant reference for AZD 3147, please let us know.

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Citations for AZD 3147

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Literature in this Area

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Pathways for AZD 3147

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.