AZD 3147

Discontinued Product

AZD 3147 (Cat. No. 5615) has been withdrawn from sale for commercial reasons.
Description: Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
Chemical Name: N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity for AZD 3147

AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

Compound Libraries for AZD 3147

AZD 3147 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 3147

M. Wt 517.66
Formula C24H31N5O4S2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1101810-02-9
PubChem ID 25168990
InChI Key JWGVUDPAMQEIJU-INIZCTEOSA-N
Smiles OCCNC(NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5[C@@H](C)COCC5)=N2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AZD 3147

References are publications that support the biological activity of the product.

Pike et al (2015) Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 58 2326 PMID: 25643210

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Citations for AZD 3147

Citations are publications that use Tocris products.

Currently there are no citations for AZD 3147.

Reviews for AZD 3147

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for AZD 3147

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.