AZD 3147

Pricing Availability Delivery Time Qty
Cat.No. 5615 - AZD 3147 | C24H31N5O4S2 | CAS No. 1101810-02-9
Description: Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
Chemical Name: N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Potent and selective dual mTORC1 and 2 inhibitor (IC50 = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

Compound Libraries

AZD 3147 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 517.66
Formula C24H31N5O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1101810-02-9
PubChem ID 25168990
InChI Key JWGVUDPAMQEIJU-INIZCTEOSA-N
Smiles OCCNC(NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5[C@@H](C)COCC5)=N2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 51.77 100
DMSO 51.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 517.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pike et al (2015) Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 58 2326 PMID: 25643210


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Citations for AZD 3147

Citations are publications that use Tocris products.

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Reviews

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Literature in this Area

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Cancer Research Product Guide

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  • Cancer Metabolism
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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
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Pain

Pain Research Product Guide

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Pathways for AZD 3147

mTOR

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.

Protocols

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