AR-M 1000390 hydrochloride

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Cat.No. 4335 - AR-M 1000390 hydrochloride | C23H28N2O.HCl | CAS No. 209808-47-9
Description: Low-internalizing δ agonist
Chemical Name: N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)-benzamide hydrochloride
Purity: ≥97% (HPLC)
Citations (1)
Literature (5)

Biological Activity

Non-peptidic, low-internalizing δ-selective opioid receptor agonist; derivative of SNC 80 (Cat. No. 0764). Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.

Technical Data

M. Wt 384.94
Formula C23H28N2O.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 209808-47-9
PubChem ID 76848958
Smiles O=C(N(CC)CC)C1=CC=C(/C(C3=CC=CC=C3)=C2\CCNCC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 38.49 100
DMSO 38.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 384.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 12.99 mL 25.98 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Marie et al (2003) Pharmacological characterization of AR-M1000390 at human opioid delta receptors. Life Sci. 73 1691 PMID: 12875901

Pradhan et al (2010) Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance. J.Neurosci. 30 16459 PMID: 21147985

If you know of a relevant reference for AR-M 1000390 hydrochloride, please let us know.

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1 Citation for AR-M 1000390 hydrochloride

Citations are publications that use Tocris products. Selected citations for AR-M 1000390 hydrochloride include:

Stoeber et al (2018) A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron 98 963 PMID: 29754753

Do you know of a great paper that uses AR-M 1000390 hydrochloride from Tocris? Please let us know.

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