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AR-M 1000390 hydrochloride
Biological Activity for AR-M 1000390 hydrochloride
AR-M 1000390 hydrochloride is a non-peptidic, low-internalizing δ-selective opioid receptor agonist; derivative of SNC 80 (Cat. No. 0764). Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.
Technical Data for AR-M 1000390 hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AR-M 1000390 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AR-M 1000390 hydrochloride
The following data is based on the product molecular weight 384.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.6 mL||12.99 mL||25.98 mL|
|5 mM||0.52 mL||2.6 mL||5.2 mL|
|10 mM||0.26 mL||1.3 mL||2.6 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
Product Datasheets for AR-M 1000390 hydrochloride
References for AR-M 1000390 hydrochloride
References are publications that support the biological activity of the product.
Marie et al (2003) Pharmacological characterization of AR-M1000390 at human opioid delta receptors. Life Sci. 73 1691 PMID: 12875901
Pradhan et al (2010) Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance. J.Neurosci. 30 16459 PMID: 21147985
If you know of a relevant reference for AR-M 1000390 hydrochloride, please let us know.
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Keywords: AR-M 1000390 hydrochloride, AR-M 1000390 hydrochloride supplier, AR-M1000390, HCl, delta, opioids, δ-opioid, receptors, agonists, Delta, Opioid, Receptors, 4335, Tocris Bioscience
3 Citations for AR-M 1000390 hydrochloride
Citations are publications that use Tocris products. Selected citations for AR-M 1000390 hydrochloride include:
Stoeber et al (2018) A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron 98 963 PMID: 29754753
Francesco Luigi et al (2023) Subcellular location defines GPCR signal transduction. Sci Adv 9 eadf6059 PMID: 37075112
Anika et al (2020) Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Sci Rep 10 8585 PMID: 32444688
Do you know of a great paper that uses AR-M 1000390 hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.