AR-M 1000390 hydrochloride

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Description: Low-internalizing δ agonist
Chemical Name: N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)-benzamide hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (2)

Biological Activity for AR-M 1000390 hydrochloride

AR-M 1000390 hydrochloride is a non-peptidic, low-internalizing δ-selective opioid receptor agonist; derivative of SNC 80 (Cat. No. 0764). Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.

Technical Data for AR-M 1000390 hydrochloride

M. Wt 384.94
Formula C23H28N2O.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 209808-47-9
PubChem ID 76848958
InChI Key OTXTZCLQEGSAMW-UHFFFAOYSA-N
Smiles O=C(N(CC)CC)C1=CC=C(/C(C3=CC=CC=C3)=C2\CCNCC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AR-M 1000390 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 38.49 100
DMSO 38.49 100

Preparing Stock Solutions for AR-M 1000390 hydrochloride

The following data is based on the product molecular weight 384.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 12.99 mL 25.98 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for AR-M 1000390 hydrochloride

Certificate of Analysis / Product Datasheet
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References for AR-M 1000390 hydrochloride

References are publications that support the biological activity of the product.

Marie et al (2003) Pharmacological characterization of AR-M1000390 at human opioid delta receptors. Life Sci. 73 1691 PMID: 12875901

Pradhan et al (2010) Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance. J.Neurosci. 30 16459 PMID: 21147985


If you know of a relevant reference for AR-M 1000390 hydrochloride, please let us know.

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Keywords: AR-M 1000390 hydrochloride, AR-M 1000390 hydrochloride supplier, AR-M1000390, HCl, delta, opioids, δ-opioid, receptors, agonists, Delta, Opioid, Receptors, 4335, Tocris Bioscience

3 Citations for AR-M 1000390 hydrochloride

Citations are publications that use Tocris products. Selected citations for AR-M 1000390 hydrochloride include:

Stoeber et al (2018) A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron 98 963 PMID: 29754753

Francesco Luigi et al (2023) Subcellular location defines GPCR signal transduction. Sci Adv 9 eadf6059 PMID: 37075112

Anika et al (2020) Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Sci Rep 10 8585 PMID: 32444688


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Reviews for AR-M 1000390 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.